Improved influenza vaccine responses after expression of multiple viral glycoproteins from a single mRNA

Abstract Influenza viruses cause substantial morbidity and mortality every year despite seasonal vaccination. mRNA-based vaccines have the potential to elicit more protective immune responses, but for maximal breadth and durability, it is desirable to deliver both the viral hemagglutinin and neurami...

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Détails bibliographiques
Auteurs principaux: Rebecca A. Leonard, Kaitlyn N. Burke, Rachel L. Spreng, Andrew N. Macintyre, Ying Tam, Mohamad-Gabriel Alameh, Drew Weissman, Nicholas S. Heaton
Format: Article
Langue:English
Publié: Nature Portfolio 2024-10-01
Collection:Nature Communications
Accès en ligne:https://doi.org/10.1038/s41467-024-52940-z