Improved influenza vaccine responses after expression of multiple viral glycoproteins from a single mRNA

Abstract Influenza viruses cause substantial morbidity and mortality every year despite seasonal vaccination. mRNA-based vaccines have the potential to elicit more protective immune responses, but for maximal breadth and durability, it is desirable to deliver both the viral hemagglutinin and neurami...

ver descrição completa

Detalhes bibliográficos
Principais autores: Rebecca A. Leonard, Kaitlyn N. Burke, Rachel L. Spreng, Andrew N. Macintyre, Ying Tam, Mohamad-Gabriel Alameh, Drew Weissman, Nicholas S. Heaton
Formato: Artigo
Idioma:English
Publicado em: Nature Portfolio 2024-10-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-024-52940-z