Disease modeling by efficient genome editing using a near PAM-less base editor in vivo

Disease modeling by efficient genome editing using a near PAM-less base editor in vivo

Abstract Base Editors are emerging as an innovative technology to introduce point mutations in complex genomes. So far, the requirement of an NGG Protospacer Adjacent Motif (PAM) at a suitable position often limits the base editing possibility to model human pathological mutations in animals. Here w...

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Bibliografiska uppgifter
Huvudupphovsmän: Marion Rosello, Malo Serafini, Luca Mignani, Dario Finazzi, Carine Giovannangeli, Marina C. Mione, Jean-Paul Concordet, Filippo Del Bene
Materialtyp: Artikel
Språk:English
Publicerad: Nature Portfolio 2022-06-01
Serie:Nature Communications
Länkar:https://doi.org/10.1038/s41467-022-31172-z

Internet

https://doi.org/10.1038/s41467-022-31172-z

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