A Systematic Study on Zinc-Related Metabolism in Breast Cancer
Breast cancer has become the most common cancer worldwide. Despite the major advances made in the past few decades in the treatment of breast cancer using a combination of chemotherapy, endocrine therapy, and immunotherapy, the genesis, treatment, recurrence, and metastasis of this disease continue...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/7/1703 |
| _version_ | 1797607308333678592 |
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| author | Zheng Qu Qiang Liu Xiangyi Kong Xiangyu Wang Zhongzhao Wang Jing Wang Yi Fang |
| author_facet | Zheng Qu Qiang Liu Xiangyi Kong Xiangyu Wang Zhongzhao Wang Jing Wang Yi Fang |
| author_sort | Zheng Qu |
| collection | DOAJ |
| description | Breast cancer has become the most common cancer worldwide. Despite the major advances made in the past few decades in the treatment of breast cancer using a combination of chemotherapy, endocrine therapy, and immunotherapy, the genesis, treatment, recurrence, and metastasis of this disease continue to pose significant difficulties. New treatment approaches are therefore urgently required. Zinc is an important trace element that is involved in regulating various enzymatic, metabolic, and cellular processes in the human body. Several studies have shown that abnormal zinc homeostasis can lead to the onset and progression of various diseases, including breast cancer. This review highlights the role played by zinc transporters in pathogenesis, apoptosis, signal transduction, and potential clinical applications in breast cancer. Additionally, the translation of the clinical applications of zinc and associated molecules in breast cancer, as well as the recent developments in the zinc-related drug targets for breast cancer treatment, is discussed. These developments offer novel insights into understanding the concepts and approaches that could be used for the diagnosis and management of breast cancer. |
| first_indexed | 2024-03-11T05:28:19Z |
| format | Article |
| id | doaj.art-f45d422dc1d646acb1c424ff12b2fb83 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-11T05:28:19Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f45d422dc1d646acb1c424ff12b2fb832023-11-17T17:20:50ZengMDPI AGNutrients2072-66432023-03-01157170310.3390/nu15071703A Systematic Study on Zinc-Related Metabolism in Breast CancerZheng Qu0Qiang Liu1Xiangyi Kong2Xiangyu Wang3Zhongzhao Wang4Jing Wang5Yi Fang6Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaDepartment of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, ChinaBreast cancer has become the most common cancer worldwide. Despite the major advances made in the past few decades in the treatment of breast cancer using a combination of chemotherapy, endocrine therapy, and immunotherapy, the genesis, treatment, recurrence, and metastasis of this disease continue to pose significant difficulties. New treatment approaches are therefore urgently required. Zinc is an important trace element that is involved in regulating various enzymatic, metabolic, and cellular processes in the human body. Several studies have shown that abnormal zinc homeostasis can lead to the onset and progression of various diseases, including breast cancer. This review highlights the role played by zinc transporters in pathogenesis, apoptosis, signal transduction, and potential clinical applications in breast cancer. Additionally, the translation of the clinical applications of zinc and associated molecules in breast cancer, as well as the recent developments in the zinc-related drug targets for breast cancer treatment, is discussed. These developments offer novel insights into understanding the concepts and approaches that could be used for the diagnosis and management of breast cancer.https://www.mdpi.com/2072-6643/15/7/1703breast cancerzinczinc transporterscancer therapymetabolism |
| spellingShingle | Zheng Qu Qiang Liu Xiangyi Kong Xiangyu Wang Zhongzhao Wang Jing Wang Yi Fang A Systematic Study on Zinc-Related Metabolism in Breast Cancer Nutrients breast cancer zinc zinc transporters cancer therapy metabolism |
| title | A Systematic Study on Zinc-Related Metabolism in Breast Cancer |
| title_full | A Systematic Study on Zinc-Related Metabolism in Breast Cancer |
| title_fullStr | A Systematic Study on Zinc-Related Metabolism in Breast Cancer |
| title_full_unstemmed | A Systematic Study on Zinc-Related Metabolism in Breast Cancer |
| title_short | A Systematic Study on Zinc-Related Metabolism in Breast Cancer |
| title_sort | systematic study on zinc related metabolism in breast cancer |
| topic | breast cancer zinc zinc transporters cancer therapy metabolism |
| url | https://www.mdpi.com/2072-6643/15/7/1703 |
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