Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry

Abstract Introduction The purpose of this study is to compare online neuropsychological test performance of older adults across self‐reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to determine the association of memory conc...

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Main Authors: R. Scott Mackin, Philip S. Insel, Diana Truran, Shannon Finley, Derek Flenniken, Rachel Nosheny, Aaron Ulbright, Monica Comacho, David Bickford, Brian Harel, Paul Maruff, Michael W. Weiner
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Online Access:https://doi.org/10.1016/j.dadm.2018.05.005
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author R. Scott Mackin
Philip S. Insel
Diana Truran
Shannon Finley
Derek Flenniken
Rachel Nosheny
Aaron Ulbright
Monica Comacho
David Bickford
Brian Harel
Paul Maruff
Michael W. Weiner
author_facet R. Scott Mackin
Philip S. Insel
Diana Truran
Shannon Finley
Derek Flenniken
Rachel Nosheny
Aaron Ulbright
Monica Comacho
David Bickford
Brian Harel
Paul Maruff
Michael W. Weiner
author_sort R. Scott Mackin
collection DOAJ
description Abstract Introduction The purpose of this study is to compare online neuropsychological test performance of older adults across self‐reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to determine the association of memory concerns and family history of dementia on cognitive performance. Methods Participants completed the Cogstate Brief Battery unsupervised at home. Results Data from 6463 participants over the age of 55 years were analyzed. Adults with the diagnosis of mild cognitive impairment and Alzheimer's disease were associated with poorer performance on all cognitive tests than cognitively normal adults (P < .05 for all), and online cognitive test performance significantly improved diagnostic classification (P < .001). Poorer performance on all cognitive measures was associated with memory concern (P < .001 for all) but not family history of dementia. Discussion Our results provide preliminary support for the use of cognitive tests taken online without supervision as a means to improve the efficiency of participant screening and recruitment for clinical trials.
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spelling doaj.art-f45d616cc9fe4211a276075c4e9ba8f12022-12-21T19:36:49ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292018-01-0110157358210.1016/j.dadm.2018.05.005Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health RegistryR. Scott Mackin0Philip S. Insel1Diana Truran2Shannon Finley3Derek Flenniken4Rachel Nosheny5Aaron Ulbright6Monica Comacho7David Bickford8Brian Harel9Paul Maruff10Michael W. Weiner11Department of PsychiatryUniversity of CaliforniaSan FranciscoCAUSACenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical CenterSan FranciscoCAUSACenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical CenterSan FranciscoCAUSACenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical CenterSan FranciscoCAUSACenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical CenterSan FranciscoCAUSACenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical CenterSan FranciscoCAUSACenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical CenterSan FranciscoCAUSACenter for Imaging of Neurodegenerative Diseases (CIND) San Francisco Veterans Affair Medical CenterSan FranciscoCAUSADepartment of PsychiatryUniversity of CaliforniaSan FranciscoCAUSAPfizerUSACogstate IncUSADepartment of PsychiatryUniversity of CaliforniaSan FranciscoCAUSAAbstract Introduction The purpose of this study is to compare online neuropsychological test performance of older adults across self‐reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer's disease and to determine the association of memory concerns and family history of dementia on cognitive performance. Methods Participants completed the Cogstate Brief Battery unsupervised at home. Results Data from 6463 participants over the age of 55 years were analyzed. Adults with the diagnosis of mild cognitive impairment and Alzheimer's disease were associated with poorer performance on all cognitive tests than cognitively normal adults (P < .05 for all), and online cognitive test performance significantly improved diagnostic classification (P < .001). Poorer performance on all cognitive measures was associated with memory concern (P < .001 for all) but not family history of dementia. Discussion Our results provide preliminary support for the use of cognitive tests taken online without supervision as a means to improve the efficiency of participant screening and recruitment for clinical trials.https://doi.org/10.1016/j.dadm.2018.05.005Brain health registryOnline cognitive testsInternetMemoryAttentionInformation‐processing speed
spellingShingle R. Scott Mackin
Philip S. Insel
Diana Truran
Shannon Finley
Derek Flenniken
Rachel Nosheny
Aaron Ulbright
Monica Comacho
David Bickford
Brian Harel
Paul Maruff
Michael W. Weiner
Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Brain health registry
Online cognitive tests
Internet
Memory
Attention
Information‐processing speed
title Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_full Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_fullStr Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_full_unstemmed Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_short Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry
title_sort unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia results from the brain health registry
topic Brain health registry
Online cognitive tests
Internet
Memory
Attention
Information‐processing speed
url https://doi.org/10.1016/j.dadm.2018.05.005
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