Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysis
Abstract Background Globally, epidemiological evidence suggests cancer incidence and outcomes among Indigenous peoples are a growing concern. Although historically cancer among First Nations (FN) peoples in Canada was relatively unknown, recent epidemiological evidence reveals a widening of cancer r...
| मुख्य लेखकों: | , , , , , , , , , , |
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| स्वरूप: | लेख |
| भाषा: | English |
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BMC
2019-11-01
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| श्रृंखला: | BMC Cancer |
| विषय: | |
| ऑनलाइन पहुंच: | http://link.springer.com/article/10.1186/s12885-019-6296-7 |
| _version_ | 1831800436765491200 |
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| author | Tara C. Horrill Lindsey Dahl Esther Sanderson Garry Munro Cindy Garson Carole Taylor Randy Fransoo Genevieve Thompson Catherine Cook Janice Linton Annette S. H. Schultz |
| author_facet | Tara C. Horrill Lindsey Dahl Esther Sanderson Garry Munro Cindy Garson Carole Taylor Randy Fransoo Genevieve Thompson Catherine Cook Janice Linton Annette S. H. Schultz |
| author_sort | Tara C. Horrill |
| collection | DOAJ |
| description | Abstract Background Globally, epidemiological evidence suggests cancer incidence and outcomes among Indigenous peoples are a growing concern. Although historically cancer among First Nations (FN) peoples in Canada was relatively unknown, recent epidemiological evidence reveals a widening of cancer related disparities. However evidence at the population level is limited. The aim of this study was to explore cancer incidence, stage at diagnosis, and outcomes among status FN peoples in comparison with all other Manitobans (AOM). Methods All cancers diagnosed between April 1, 2004 and March 31, 2011 were linked with the Indian Registry System and five provincial healthcare databases to compare differences in characteristics, cancer incidence, and stage at diagnosis and mortality of the FN and AOM cohorts. Cox proportional hazard regression models were used to examine mortality. Results The FN cohort was significantly younger, with higher comorbidities than AOM. A higher proportion of FN people were diagnosed with cancer at stages III (18.7% vs. 15.4%) and IV (22.4% vs. 19.9%). Cancer incidence was significantly lower in the FN cohort, however, there were no significant differences between the two cohorts after adjusting for age, sex, income and area of residence. No significant trends in cancer incidence were identified in either cohort over time. Mortality was generally higher in the FN cohort. Conclusions Despite similar cancer incidence, FN peoples in Manitoba experience poorer survival. The underlying causes of these disparities are not yet understood, particularly in relation to the impact of colonization and other determinants of health. |
| first_indexed | 2024-12-22T18:03:44Z |
| format | Article |
| id | doaj.art-f45dca4570eb4f6b8e543e85831c554c |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-22T18:03:44Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f45dca4570eb4f6b8e543e85831c554c2022-12-21T18:17:49ZengBMCBMC Cancer1471-24072019-11-0119111010.1186/s12885-019-6296-7Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysisTara C. Horrill0Lindsey Dahl1Esther Sanderson2Garry Munro3Cindy Garson4Carole Taylor5Randy Fransoo6Genevieve Thompson7Catherine Cook8Janice Linton9Annette S. H. Schultz10College of Nursing, Rady Faculty of Health Sciences, University of ManitobaRady Faculty of Health Sciences, University of ManitobaUniversity College of the NorthCree Nation Tribal Health CentreInterlake Reserves Tribal CouncilManitoba Centre for Health Policy, University of ManitobaManitoba Centre for Health Policy, University of ManitobaCollege of Nursing, Rady Faculty of Health Sciences, University of ManitobaRady Faculty of Health Sciences, University of ManitobaIndigenous Health Librarian, University of ManitobaCollege of Nursing, Rady Faculty of Health Sciences, University of ManitobaAbstract Background Globally, epidemiological evidence suggests cancer incidence and outcomes among Indigenous peoples are a growing concern. Although historically cancer among First Nations (FN) peoples in Canada was relatively unknown, recent epidemiological evidence reveals a widening of cancer related disparities. However evidence at the population level is limited. The aim of this study was to explore cancer incidence, stage at diagnosis, and outcomes among status FN peoples in comparison with all other Manitobans (AOM). Methods All cancers diagnosed between April 1, 2004 and March 31, 2011 were linked with the Indian Registry System and five provincial healthcare databases to compare differences in characteristics, cancer incidence, and stage at diagnosis and mortality of the FN and AOM cohorts. Cox proportional hazard regression models were used to examine mortality. Results The FN cohort was significantly younger, with higher comorbidities than AOM. A higher proportion of FN people were diagnosed with cancer at stages III (18.7% vs. 15.4%) and IV (22.4% vs. 19.9%). Cancer incidence was significantly lower in the FN cohort, however, there were no significant differences between the two cohorts after adjusting for age, sex, income and area of residence. No significant trends in cancer incidence were identified in either cohort over time. Mortality was generally higher in the FN cohort. Conclusions Despite similar cancer incidence, FN peoples in Manitoba experience poorer survival. The underlying causes of these disparities are not yet understood, particularly in relation to the impact of colonization and other determinants of health.http://link.springer.com/article/10.1186/s12885-019-6296-7CancerMortalityNeoplasmsIndigenousFirst NationsCanada |
| spellingShingle | Tara C. Horrill Lindsey Dahl Esther Sanderson Garry Munro Cindy Garson Carole Taylor Randy Fransoo Genevieve Thompson Catherine Cook Janice Linton Annette S. H. Schultz Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysis BMC Cancer Cancer Mortality Neoplasms Indigenous First Nations Canada |
| title | Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysis |
| title_full | Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysis |
| title_fullStr | Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysis |
| title_full_unstemmed | Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysis |
| title_short | Comparing cancer incidence, stage at diagnosis and outcomes of First Nations and all other Manitobans: a retrospective analysis |
| title_sort | comparing cancer incidence stage at diagnosis and outcomes of first nations and all other manitobans a retrospective analysis |
| topic | Cancer Mortality Neoplasms Indigenous First Nations Canada |
| url | http://link.springer.com/article/10.1186/s12885-019-6296-7 |
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