Alarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 years
Abstract The increasing rates of antibiotic resistance in Helicobacter pylori (H. pylori) are a major concern of the decreasing eradication rate. Large-scale and long-period studies on antimicrobial susceptibility of H. pylori in children are limited. This study aimed to describe the temporal change...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-21661-y |
| _version_ | 1811250020660281344 |
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| author | Xiaoli Shu Diya Ye Chenmin Hu Kerong Peng Hong Zhao Huamei Li Mizu Jiang |
| author_facet | Xiaoli Shu Diya Ye Chenmin Hu Kerong Peng Hong Zhao Huamei Li Mizu Jiang |
| author_sort | Xiaoli Shu |
| collection | DOAJ |
| description | Abstract The increasing rates of antibiotic resistance in Helicobacter pylori (H. pylori) are a major concern of the decreasing eradication rate. Large-scale and long-period studies on antimicrobial susceptibility of H. pylori in children are limited. This study aimed to describe the temporal changes of antibiotic resistance among children in southeast China. Gastric biopsies obtained from children were cultured for H. pylori from 2015 to 2020. Susceptibility to clarithromycin (CLA), amoxicillin (AML), metronidazole (MTZ), furazolidone (FZD), tetracycline (TET) and levofloxacin (LEV) was tested. Data from 2012 to 2014 reported previously were obtained for comparing the change in temporal trends of antibiotic resistance. A total of 1638 (52.7%) H. pylori strains were isolated from 3111 children recruited. The resistance rates to CLA, MTZ and LEV were 32.8%, 81.7% and 22.8%, respectively. There were 52.9% strains resistant to single resistance, 28.7% to double resistance, and 9.0% to triple resistance. The total resistance rate and resistance rates to CLA, MTZ, LEV, CLA + LEV and CLA + MTZ + LEV increased annually in a linear manner. All resistant patterns except single resistance increased obviously from 2015 to 2017 and 2018 to 2020 compared to that from 2012 to 2014. Double resistance to CLA + MTZ increased significantly with age. The resistance rate to CLA and triple resistance to CLA, MTZ and LEV increased in children with prior H. pylori treatment than that from children without prior treatment. The antibiotic resistance rates of H. pylori were high in a large pediatric population in southeast China from 2015 to 2020. Individual treatment based on susceptibility test is imperative and optimal regimens should be chosen in H. pylori eradication therapy. |
| first_indexed | 2024-04-12T15:57:46Z |
| format | Article |
| id | doaj.art-f45e2f1d5b19458eb38cba57b85e3ee2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T15:57:46Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f45e2f1d5b19458eb38cba57b85e3ee22022-12-22T03:26:19ZengNature PortfolioScientific Reports2045-23222022-10-011211810.1038/s41598-022-21661-yAlarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 yearsXiaoli Shu0Diya Ye1Chenmin Hu2Kerong Peng3Hong Zhao4Huamei Li5Mizu Jiang6Gastrointestinal Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterGastrointestinal Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterGastrointestinal Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterDepartment of Gastroenterology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterDepartment of Gastroenterology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterGastrointestinal Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterGastrointestinal Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterAbstract The increasing rates of antibiotic resistance in Helicobacter pylori (H. pylori) are a major concern of the decreasing eradication rate. Large-scale and long-period studies on antimicrobial susceptibility of H. pylori in children are limited. This study aimed to describe the temporal changes of antibiotic resistance among children in southeast China. Gastric biopsies obtained from children were cultured for H. pylori from 2015 to 2020. Susceptibility to clarithromycin (CLA), amoxicillin (AML), metronidazole (MTZ), furazolidone (FZD), tetracycline (TET) and levofloxacin (LEV) was tested. Data from 2012 to 2014 reported previously were obtained for comparing the change in temporal trends of antibiotic resistance. A total of 1638 (52.7%) H. pylori strains were isolated from 3111 children recruited. The resistance rates to CLA, MTZ and LEV were 32.8%, 81.7% and 22.8%, respectively. There were 52.9% strains resistant to single resistance, 28.7% to double resistance, and 9.0% to triple resistance. The total resistance rate and resistance rates to CLA, MTZ, LEV, CLA + LEV and CLA + MTZ + LEV increased annually in a linear manner. All resistant patterns except single resistance increased obviously from 2015 to 2017 and 2018 to 2020 compared to that from 2012 to 2014. Double resistance to CLA + MTZ increased significantly with age. The resistance rate to CLA and triple resistance to CLA, MTZ and LEV increased in children with prior H. pylori treatment than that from children without prior treatment. The antibiotic resistance rates of H. pylori were high in a large pediatric population in southeast China from 2015 to 2020. Individual treatment based on susceptibility test is imperative and optimal regimens should be chosen in H. pylori eradication therapy.https://doi.org/10.1038/s41598-022-21661-y |
| spellingShingle | Xiaoli Shu Diya Ye Chenmin Hu Kerong Peng Hong Zhao Huamei Li Mizu Jiang Alarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 years Scientific Reports |
| title | Alarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 years |
| title_full | Alarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 years |
| title_fullStr | Alarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 years |
| title_full_unstemmed | Alarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 years |
| title_short | Alarming antibiotics resistance of Helicobacter pylori from children in Southeast China over 6 years |
| title_sort | alarming antibiotics resistance of helicobacter pylori from children in southeast china over 6 years |
| url | https://doi.org/10.1038/s41598-022-21661-y |
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