BIOPHARMACEUTICAL CLASSIFICATIOM SYSTEM AS A TOOL FOR THE DEVELOPMENT OF DRUG FORMULATIONS AND THEIR DESIGNS
The article analyzes and systematizes approaches to justification of drug formulation technology, depending on the API`s biopharmaceutical classification system (BCS). The solubility and absorption inherent to BCS are the most important characteristic of pharmaceutical substances and should be the f...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
|
| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/407 |
| Summary: | The article analyzes and systematizes approaches to justification of drug formulation technology, depending on the API`s biopharmaceutical classification system (BCS). The solubility and absorption inherent to BCS are the most important characteristic of pharmaceutical substances and should be the factor of rational justification of formulations and technologies for safe medicines. Article shows the overview of modern biopharmaceutical technology for improving the characteristics of API, which are belongs to different classes of BCS. Were shown that during the development of dosage forms with poorly soluble APIs is better to use technology solubility enhancement, for substances of IIIrd and IVth classes - needs to increase absorption. Article describes the design of dosage form of successful medicinal products. |
|---|---|
| ISSN: | 2305-2066 2658-5049 |