Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis
Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/5/1026 |
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| author | Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Dimitrios Kazantzis Jorge Sanz-Sánchez Sotiria G. Giotaki Konstantinos Raisakis Andreas Kaoukis Charalampos Kossyvakis Gerasimos Deftereos Bernhard Reimers Dimitrios Avramides Gerasimos Siasos Michael Cleman George Giannopoulos Alexandra Lansky Spyridon Deftereos |
| author_facet | Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Dimitrios Kazantzis Jorge Sanz-Sánchez Sotiria G. Giotaki Konstantinos Raisakis Andreas Kaoukis Charalampos Kossyvakis Gerasimos Deftereos Bernhard Reimers Dimitrios Avramides Gerasimos Siasos Michael Cleman George Giannopoulos Alexandra Lansky Spyridon Deftereos |
| author_sort | Dimitrios A. Vrachatis |
| collection | DOAJ |
| description | Isolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation. |
| first_indexed | 2024-03-10T03:04:23Z |
| format | Article |
| id | doaj.art-f460e1d0aaa8453f9fbda2b1a58a73e6 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T03:04:23Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f460e1d0aaa8453f9fbda2b1a58a73e62023-11-23T10:38:15ZengMDPI AGDiagnostics2075-44182022-04-01125102610.3390/diagnostics12051026Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-AnalysisDimitrios A. Vrachatis0Konstantinos A. Papathanasiou1Dimitrios Kazantzis2Jorge Sanz-Sánchez3Sotiria G. Giotaki4Konstantinos Raisakis5Andreas Kaoukis6Charalampos Kossyvakis7Gerasimos Deftereos8Bernhard Reimers9Dimitrios Avramides10Gerasimos Siasos11Michael Cleman12George Giannopoulos13Alexandra Lansky14Spyridon Deftereos15Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMedical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMedical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDivision of Cardiology, Hospital Universitario y Politécnico La Fe, 46026 Valencia, SpainMedical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceDeparment of Cardiology, General Hospital of Athens “G.Gennimatas”, 11527 Athens, GreeceDeparment of Cardiology, General Hospital of Athens “G.Gennimatas”, 11527 Athens, GreeceDeparment of Cardiology, General Hospital of Athens “G.Gennimatas”, 11527 Athens, GreeceDeparment of Cardiology, General Hospital of Athens “G.Gennimatas”, 11527 Athens, GreeceHumanitas Clinical and Research Center IRCCS, 20089 Milan, ItalyDeparment of Cardiology, General Hospital of Athens “G.Gennimatas”, 11527 Athens, GreeceMedical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USAMedical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceSection of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USAMedical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceIsolated coronary artery ectasia (CAE) is a relatively rare clinical entity, the pathogenesis of which is poorly understood. More and more evidence is accumulating to suggest a critical inflammatory component. We aimed to elucidate any association between neutrophil to lymphocyte ratio and coronary artery ectasia. A systematic MEDLINE database, ClinicalTrials.gov, medRxiv, Scopus and Cochrane Library search was conducted: 50 studies were deemed relevant, reporting on difference in NLR levels between CAE patients and controls (primary endpoint) and/or on high-sensitive CRP, IL-6, TNF-a and RDW levels (secondary endpoint), and were included in our final analysis. (PROSPERO registration number: CRD42021224195). All inflammatory biomarkers under investigation were found higher in coronary artery ectasia patients as compared to healthy controls (NLR; SMD = 0.73; 95% CI: 0.27–1.20, hs-CRP; SMD = 0.96; 95% CI: 0.64–1.28, IL-6; SMD = 2.68; 95% CI: 0.95–4.41, TNF-a; SMD = 0.50; 95% CI: 0.24–0.75, RDW; SMD = 0.56; 95% CI: 0.26–0.87). The main limitations inherent in this analysis are small case-control studies of moderate quality and high statistical heterogeneity. Our findings underscore that inflammatory dysregulation is implicated in coronary artery ectasia and merits further investigation.https://www.mdpi.com/2075-4418/12/5/1026coronary artery ectasiainflammationbiomarkersneutrophil lymphocyte ratio |
| spellingShingle | Dimitrios A. Vrachatis Konstantinos A. Papathanasiou Dimitrios Kazantzis Jorge Sanz-Sánchez Sotiria G. Giotaki Konstantinos Raisakis Andreas Kaoukis Charalampos Kossyvakis Gerasimos Deftereos Bernhard Reimers Dimitrios Avramides Gerasimos Siasos Michael Cleman George Giannopoulos Alexandra Lansky Spyridon Deftereos Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis Diagnostics coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio |
| title | Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis |
| title_full | Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis |
| title_fullStr | Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis |
| title_short | Inflammatory Biomarkers in Coronary Artery Ectasia: A Systematic Review and Meta-Analysis |
| title_sort | inflammatory biomarkers in coronary artery ectasia a systematic review and meta analysis |
| topic | coronary artery ectasia inflammation biomarkers neutrophil lymphocyte ratio |
| url | https://www.mdpi.com/2075-4418/12/5/1026 |
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