A prebiotic template-directed peptide synthesis based on amyloids
Amyloids may have played an important role in prebiotic molecular evolution but understanding replication of such information-coding molecules is still a problem. Here the authors design a model amyloid substrate and demonstrate sequence regio- and stereoselectivity during template-based replication...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02742-3 |
| _version_ | 1818750449302372352 |
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| author | Saroj K. Rout Michael P. Friedmann Roland Riek Jason Greenwald |
| author_facet | Saroj K. Rout Michael P. Friedmann Roland Riek Jason Greenwald |
| author_sort | Saroj K. Rout |
| collection | DOAJ |
| description | Amyloids may have played an important role in prebiotic molecular evolution but understanding replication of such information-coding molecules is still a problem. Here the authors design a model amyloid substrate and demonstrate sequence regio- and stereoselectivity during template-based replication. |
| first_indexed | 2024-12-18T04:19:51Z |
| format | Article |
| id | doaj.art-f4617bced55d408e84bbb721d41321de |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T04:19:51Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f4617bced55d408e84bbb721d41321de2022-12-21T21:21:16ZengNature PortfolioNature Communications2041-17232018-01-01911810.1038/s41467-017-02742-3A prebiotic template-directed peptide synthesis based on amyloidsSaroj K. Rout0Michael P. Friedmann1Roland Riek2Jason Greenwald3Laboratory of Physical Chemistry, ETH ZürichLaboratory of Physical Chemistry, ETH ZürichLaboratory of Physical Chemistry, ETH ZürichLaboratory of Physical Chemistry, ETH ZürichAmyloids may have played an important role in prebiotic molecular evolution but understanding replication of such information-coding molecules is still a problem. Here the authors design a model amyloid substrate and demonstrate sequence regio- and stereoselectivity during template-based replication.https://doi.org/10.1038/s41467-017-02742-3 |
| spellingShingle | Saroj K. Rout Michael P. Friedmann Roland Riek Jason Greenwald A prebiotic template-directed peptide synthesis based on amyloids Nature Communications |
| title | A prebiotic template-directed peptide synthesis based on amyloids |
| title_full | A prebiotic template-directed peptide synthesis based on amyloids |
| title_fullStr | A prebiotic template-directed peptide synthesis based on amyloids |
| title_full_unstemmed | A prebiotic template-directed peptide synthesis based on amyloids |
| title_short | A prebiotic template-directed peptide synthesis based on amyloids |
| title_sort | prebiotic template directed peptide synthesis based on amyloids |
| url | https://doi.org/10.1038/s41467-017-02742-3 |
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