A prebiotic template-directed peptide synthesis based on amyloids

Amyloids may have played an important role in prebiotic molecular evolution but understanding replication of such information-coding molecules is still a problem. Here the authors design a model amyloid substrate and demonstrate sequence regio- and stereoselectivity during template-based replication...

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Bibliographic Details
Main Authors: Saroj K. Rout, Michael P. Friedmann, Roland Riek, Jason Greenwald
Format: Article
Language:English
Published: Nature Portfolio 2018-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02742-3