Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study
A Backround: Multiple sclerosis (MS) is a complex chronic disease of the central nervous system (CNS). Body mass index (BMI), a component of metabolic syndrome (MetS), is considered among the risk factors for MS. However, its role in MS remains ambiguous. Objective: To examine the impact of BMI on t...
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MDPI AG
2021-10-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/13/4/51 |
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| author | Vasileios Siokas Konstantinos Katsiardanis Athina-Maria Aloizou Christos Bakirtzis Ioannis Liampas Evangelos Koutlas Jobst Rudolf Konstantinos Ntinoulis Jannis Kountouras Efthimios Dardiotis Georgia Deretzi |
| author_facet | Vasileios Siokas Konstantinos Katsiardanis Athina-Maria Aloizou Christos Bakirtzis Ioannis Liampas Evangelos Koutlas Jobst Rudolf Konstantinos Ntinoulis Jannis Kountouras Efthimios Dardiotis Georgia Deretzi |
| author_sort | Vasileios Siokas |
| collection | DOAJ |
| description | A Backround: Multiple sclerosis (MS) is a complex chronic disease of the central nervous system (CNS). Body mass index (BMI), a component of metabolic syndrome (MetS), is considered among the risk factors for MS. However, its role in MS remains ambiguous. Objective: To examine the impact of BMI on the age of onset in patients with relapsing-remitting MS (RRMS) in a Greek cohort. Methods: Data from 821 Greek patients with RRMS were collected. The BMI values were considered as quartiles. Comparisons for the demographic characteristics between the quartiles were made by Pearson’s chi-square test for the categorical variables and by ANOVA for the continuous variables. An overall p-value was calculated corresponding to trend for association. In case of significant association, further post-hoc analysis was performed in order to identify differences in demographic characteristics between specific BMI quartiles groups. Linear regression analyses were used to assess the relationship between BMI and age at onset of MS. Results: Comparisons of participant characteristics by quartiles of BMI revealed that participants with the highest BMI had an older age of disease onset. Results from linear regression analysis showed that with each increase of 1 BMI unit, the age of RRMS onset increases by 0.255 (95% CI 0.136 to 0.374) years, <i>p</i> < 0.001. Conclusions: Patients with higher BMI, as a parameter of MetS, exhibit increased age of RRMS onset. Our results may present an alternative personalized approach for diagnosis, prognosis, and/or prevention of RRMS. |
| first_indexed | 2024-03-10T03:25:55Z |
| format | Article |
| id | doaj.art-f46378c71fea45d985aa3a396c952782 |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-10T03:25:55Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-f46378c71fea45d985aa3a396c9527822023-11-23T09:53:25ZengMDPI AGNeurology International2035-83772021-10-0113451752610.3390/neurolint13040051Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective StudyVasileios Siokas0Konstantinos Katsiardanis1Athina-Maria Aloizou2Christos Bakirtzis3Ioannis Liampas4Evangelos Koutlas5Jobst Rudolf6Konstantinos Ntinoulis7Jannis Kountouras8Efthimios Dardiotis9Georgia Deretzi10Laboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceDepartment of Neurology, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceB’ Department of Neurology, AHEPA University Hospital, Aristotle University of Thessaloniki, 54636 Thessaloniki, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceDepartment of Neurology, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceDepartment of Neurology, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceDepartment of Neurology, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceDepartment of Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, GreeceLaboratory of Neurogenetics, Department of Neurology, University Hospital of Larissa, University of Thessaly, 41110 Larissa, GreeceDepartment of Neurology, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceA Backround: Multiple sclerosis (MS) is a complex chronic disease of the central nervous system (CNS). Body mass index (BMI), a component of metabolic syndrome (MetS), is considered among the risk factors for MS. However, its role in MS remains ambiguous. Objective: To examine the impact of BMI on the age of onset in patients with relapsing-remitting MS (RRMS) in a Greek cohort. Methods: Data from 821 Greek patients with RRMS were collected. The BMI values were considered as quartiles. Comparisons for the demographic characteristics between the quartiles were made by Pearson’s chi-square test for the categorical variables and by ANOVA for the continuous variables. An overall p-value was calculated corresponding to trend for association. In case of significant association, further post-hoc analysis was performed in order to identify differences in demographic characteristics between specific BMI quartiles groups. Linear regression analyses were used to assess the relationship between BMI and age at onset of MS. Results: Comparisons of participant characteristics by quartiles of BMI revealed that participants with the highest BMI had an older age of disease onset. Results from linear regression analysis showed that with each increase of 1 BMI unit, the age of RRMS onset increases by 0.255 (95% CI 0.136 to 0.374) years, <i>p</i> < 0.001. Conclusions: Patients with higher BMI, as a parameter of MetS, exhibit increased age of RRMS onset. Our results may present an alternative personalized approach for diagnosis, prognosis, and/or prevention of RRMS.https://www.mdpi.com/2035-8377/13/4/51body mass indexage at onsetmetabolic syndromeRRMS |
| spellingShingle | Vasileios Siokas Konstantinos Katsiardanis Athina-Maria Aloizou Christos Bakirtzis Ioannis Liampas Evangelos Koutlas Jobst Rudolf Konstantinos Ntinoulis Jannis Kountouras Efthimios Dardiotis Georgia Deretzi Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study Neurology International body mass index age at onset metabolic syndrome RRMS |
| title | Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study |
| title_full | Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study |
| title_fullStr | Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study |
| title_full_unstemmed | Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study |
| title_short | Impact of Body Mass Index on the Age of Relapsing-Remitting Multiple Sclerosis Onset: A Retrospective Study |
| title_sort | impact of body mass index on the age of relapsing remitting multiple sclerosis onset a retrospective study |
| topic | body mass index age at onset metabolic syndrome RRMS |
| url | https://www.mdpi.com/2035-8377/13/4/51 |
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