Kinase‐two‐hybrid: towards the conditional interactome

The dynamics of the protein–protein interaction network and how it responds to biological perturbations remain difficult to assay by most traditional techniques. A novel kinase‐dependent yeast two‐hybrid framework by Stelzl and colleagues (Grossmann et al, 2015) provides a new prism to study how tyr...

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Bibliographic Details
Main Authors: David Ochoa, Pedro Beltrao
Format: Article
Language:English
Published: Springer Nature 2015-03-01
Series:Molecular Systems Biology
Online Access:https://doi.org/10.15252/msb.20156107
Description
Summary:The dynamics of the protein–protein interaction network and how it responds to biological perturbations remain difficult to assay by most traditional techniques. A novel kinase‐dependent yeast two‐hybrid framework by Stelzl and colleagues (Grossmann et al, 2015) provides a new prism to study how tyrosine phosphorylation regulates the changes in the interactome under varying conditions.
ISSN:1744-4292