Expression and Roles of Teneurins in Zebrafish
The teneurins, also known as Ten-m/Odz, are highly conserved type II transmembrane glycoproteins widely expressed throughout the nervous system. Functioning as dimers, these large cell-surface adhesion proteins play a key role in regulating neurodevelopmental processes such as axon targeting, synapt...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00158/full |
| _version_ | 1818276337819844608 |
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| author | Angela Cheung Angela Cheung Katherine E. Trevers Katherine E. Trevers Marta Reyes-Corral Paride Antinucci Robert Hindges Robert Hindges |
| author_facet | Angela Cheung Angela Cheung Katherine E. Trevers Katherine E. Trevers Marta Reyes-Corral Paride Antinucci Robert Hindges Robert Hindges |
| author_sort | Angela Cheung |
| collection | DOAJ |
| description | The teneurins, also known as Ten-m/Odz, are highly conserved type II transmembrane glycoproteins widely expressed throughout the nervous system. Functioning as dimers, these large cell-surface adhesion proteins play a key role in regulating neurodevelopmental processes such as axon targeting, synaptogenesis and neuronal wiring. Synaptic specificity is driven by molecular interactions, which can occur either in a trans-homophilic manner between teneurins or through a trans-heterophilic interaction across the synaptic cleft between teneurins and other cell-adhesion molecules, such as latrophilins. The significance of teneurins interactions during development is reflected in the widespread expression pattern of the four existing paralogs across interconnected regions of the nervous system, which we demonstrate here via in situ hybridization and the generation of transgenic BAC reporter lines in zebrafish. Focusing on the visual system, we will also highlight the recent developments that have been made in furthering our understanding of teneurin interactions and their functionality, including the instructive role of teneurin-3 in specifying the functional wiring of distinct amacrine and retinal ganglion cells in the vertebrate visual system underlying a particular functionality. Based on the distinct expression pattern of all teneurins in different retinal cells, it is conceivable that the combination of different teneurins is crucial for the generation of discrete visual circuits. Finally, mutations in all four human teneurin genes have been linked to several types of neurodevelopmental disorders. The opportunity therefore arises that findings about the roles of zebrafish teneurins or their orthologs in other species shed light on the molecular mechanisms in the etiology of such human disorders. |
| first_indexed | 2024-12-12T22:44:03Z |
| format | Article |
| id | doaj.art-f46438fca4574cbda9610bc21fa9ae74 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-12T22:44:03Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-f46438fca4574cbda9610bc21fa9ae742022-12-22T00:09:16ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-03-011310.3389/fnins.2019.00158432551Expression and Roles of Teneurins in ZebrafishAngela Cheung0Angela Cheung1Katherine E. Trevers2Katherine E. Trevers3Marta Reyes-Corral4Paride Antinucci5Robert Hindges6Robert Hindges7Centre for Developmental Neurobiology, King’s College London, London, United KingdomMRC Centre for Neurodevelopmental Disorders, King’s College London, London, United KingdomCentre for Developmental Neurobiology, King’s College London, London, United KingdomMRC Centre for Neurodevelopmental Disorders, King’s College London, London, United KingdomCentre for Developmental Neurobiology, King’s College London, London, United KingdomCentre for Developmental Neurobiology, King’s College London, London, United KingdomCentre for Developmental Neurobiology, King’s College London, London, United KingdomMRC Centre for Neurodevelopmental Disorders, King’s College London, London, United KingdomThe teneurins, also known as Ten-m/Odz, are highly conserved type II transmembrane glycoproteins widely expressed throughout the nervous system. Functioning as dimers, these large cell-surface adhesion proteins play a key role in regulating neurodevelopmental processes such as axon targeting, synaptogenesis and neuronal wiring. Synaptic specificity is driven by molecular interactions, which can occur either in a trans-homophilic manner between teneurins or through a trans-heterophilic interaction across the synaptic cleft between teneurins and other cell-adhesion molecules, such as latrophilins. The significance of teneurins interactions during development is reflected in the widespread expression pattern of the four existing paralogs across interconnected regions of the nervous system, which we demonstrate here via in situ hybridization and the generation of transgenic BAC reporter lines in zebrafish. Focusing on the visual system, we will also highlight the recent developments that have been made in furthering our understanding of teneurin interactions and their functionality, including the instructive role of teneurin-3 in specifying the functional wiring of distinct amacrine and retinal ganglion cells in the vertebrate visual system underlying a particular functionality. Based on the distinct expression pattern of all teneurins in different retinal cells, it is conceivable that the combination of different teneurins is crucial for the generation of discrete visual circuits. Finally, mutations in all four human teneurin genes have been linked to several types of neurodevelopmental disorders. The opportunity therefore arises that findings about the roles of zebrafish teneurins or their orthologs in other species shed light on the molecular mechanisms in the etiology of such human disorders.https://www.frontiersin.org/article/10.3389/fnins.2019.00158/fullteneurin/Odzretinal ganglion cellamacrine cellvisual systemsynapse adhesion moleculezebrafish |
| spellingShingle | Angela Cheung Angela Cheung Katherine E. Trevers Katherine E. Trevers Marta Reyes-Corral Paride Antinucci Robert Hindges Robert Hindges Expression and Roles of Teneurins in Zebrafish Frontiers in Neuroscience teneurin/Odz retinal ganglion cell amacrine cell visual system synapse adhesion molecule zebrafish |
| title | Expression and Roles of Teneurins in Zebrafish |
| title_full | Expression and Roles of Teneurins in Zebrafish |
| title_fullStr | Expression and Roles of Teneurins in Zebrafish |
| title_full_unstemmed | Expression and Roles of Teneurins in Zebrafish |
| title_short | Expression and Roles of Teneurins in Zebrafish |
| title_sort | expression and roles of teneurins in zebrafish |
| topic | teneurin/Odz retinal ganglion cell amacrine cell visual system synapse adhesion molecule zebrafish |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00158/full |
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