Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs.
Canine hip dysplasia (CHD) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority. The typical heritability estimates for radiographic CHD traits suggest that the accuracy of breeding dog selecti...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3812223?pdf=render |
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| author | Bethany J Wilson Frank W Nicholas John W James Claire M Wade Peter C Thomson |
| author_facet | Bethany J Wilson Frank W Nicholas John W James Claire M Wade Peter C Thomson |
| author_sort | Bethany J Wilson |
| collection | DOAJ |
| description | Canine hip dysplasia (CHD) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority. The typical heritability estimates for radiographic CHD traits suggest that the accuracy of breeding dog selection could be substantially improved by the use of estimated breeding values (EBVs) in place of selection based on phenotypes of individuals. The British Veterinary Association/Kennel Club scoring method is a complex measure composed of nine bilateral ordinal traits, intended to evaluate both early and late dysplastic changes. However, the ordinal nature of the traits may represent a technical challenge for calculation of EBVs using linear methods. The purpose of the current study was to calculate EBVs of British Veterinary Association/Kennel Club traits in the Australian population of German Shepherd Dogs, using linear (both as individual traits and a summed phenotype), binary and ordinal methods to determine the optimal method for EBV calculation. Ordinal EBVs correlated well with linear EBVs (r = 0.90-0.99) and somewhat well with EBVs for the sum of the individual traits (r = 0.58-0.92). Correlation of ordinal and binary EBVs varied widely (r = 0.24-0.99) depending on the trait and cut-point considered. The ordinal EBVs have increased accuracy (0.48-0.69) of selection compared with accuracies from individual phenotype-based selection (0.40-0.52). Despite the high correlations between linear and ordinal EBVs, the underlying relationship between EBVs calculated by the two methods was not always linear, leading us to suggest that ordinal models should be used wherever possible. As the population of German Shepherd Dogs which was studied was purportedly under selection for the traits studied, we examined the EBVs for evidence of a genetic trend in these traits and found substantial genetic improvement over time. This study suggests the use of ordinal EBVs could increase the rate of genetic improvement in this population. |
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| format | Article |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T04:21:36Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-f46474daab024c609cf54a5453c1b6a82022-12-21T19:16:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7747010.1371/journal.pone.0077470Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs.Bethany J WilsonFrank W NicholasJohn W JamesClaire M WadePeter C ThomsonCanine hip dysplasia (CHD) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority. The typical heritability estimates for radiographic CHD traits suggest that the accuracy of breeding dog selection could be substantially improved by the use of estimated breeding values (EBVs) in place of selection based on phenotypes of individuals. The British Veterinary Association/Kennel Club scoring method is a complex measure composed of nine bilateral ordinal traits, intended to evaluate both early and late dysplastic changes. However, the ordinal nature of the traits may represent a technical challenge for calculation of EBVs using linear methods. The purpose of the current study was to calculate EBVs of British Veterinary Association/Kennel Club traits in the Australian population of German Shepherd Dogs, using linear (both as individual traits and a summed phenotype), binary and ordinal methods to determine the optimal method for EBV calculation. Ordinal EBVs correlated well with linear EBVs (r = 0.90-0.99) and somewhat well with EBVs for the sum of the individual traits (r = 0.58-0.92). Correlation of ordinal and binary EBVs varied widely (r = 0.24-0.99) depending on the trait and cut-point considered. The ordinal EBVs have increased accuracy (0.48-0.69) of selection compared with accuracies from individual phenotype-based selection (0.40-0.52). Despite the high correlations between linear and ordinal EBVs, the underlying relationship between EBVs calculated by the two methods was not always linear, leading us to suggest that ordinal models should be used wherever possible. As the population of German Shepherd Dogs which was studied was purportedly under selection for the traits studied, we examined the EBVs for evidence of a genetic trend in these traits and found substantial genetic improvement over time. This study suggests the use of ordinal EBVs could increase the rate of genetic improvement in this population.http://europepmc.org/articles/PMC3812223?pdf=render |
| spellingShingle | Bethany J Wilson Frank W Nicholas John W James Claire M Wade Peter C Thomson Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs. PLoS ONE |
| title | Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs. |
| title_full | Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs. |
| title_fullStr | Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs. |
| title_full_unstemmed | Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs. |
| title_short | Estimated breeding values for canine hip dysplasia radiographic traits in a cohort of Australian German Shepherd dogs. |
| title_sort | estimated breeding values for canine hip dysplasia radiographic traits in a cohort of australian german shepherd dogs |
| url | http://europepmc.org/articles/PMC3812223?pdf=render |
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