MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models.
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31331-2 |
| _version_ | 1828335270268764160 |
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| author | Ling Tao Mahmoud A. Mohammad Giorgio Milazzo Myrthala Moreno-Smith Tajhal D. Patel Barry Zorman Andrew Badachhape Blanca E. Hernandez Amber B. Wolf Zihua Zeng Jennifer H. Foster Sara Aloisi Pavel Sumazin Youli Zu John Hicks Ketan B. Ghaghada Nagireddy Putluri Giovanni Perini Cristian Coarfa Eveline Barbieri |
| author_facet | Ling Tao Mahmoud A. Mohammad Giorgio Milazzo Myrthala Moreno-Smith Tajhal D. Patel Barry Zorman Andrew Badachhape Blanca E. Hernandez Amber B. Wolf Zihua Zeng Jennifer H. Foster Sara Aloisi Pavel Sumazin Youli Zu John Hicks Ketan B. Ghaghada Nagireddy Putluri Giovanni Perini Cristian Coarfa Eveline Barbieri |
| author_sort | Ling Tao |
| collection | DOAJ |
| description | Half of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models. |
| first_indexed | 2024-04-13T21:43:58Z |
| format | Article |
| id | doaj.art-f46634316a174b53a1daa084ab8c5d23 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T21:43:58Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f46634316a174b53a1daa084ab8c5d232022-12-22T02:28:39ZengNature PortfolioNature Communications2041-17232022-06-0113111710.1038/s41467-022-31331-2MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastomaLing Tao0Mahmoud A. Mohammad1Giorgio Milazzo2Myrthala Moreno-Smith3Tajhal D. Patel4Barry Zorman5Andrew Badachhape6Blanca E. Hernandez7Amber B. Wolf8Zihua Zeng9Jennifer H. Foster10Sara Aloisi11Pavel Sumazin12Youli Zu13John Hicks14Ketan B. Ghaghada15Nagireddy Putluri16Giovanni Perini17Cristian Coarfa18Eveline Barbieri19Department of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pediatrics-Nutrition, Baylor College of MedicineDepartment of Pharmacy and Biotechnology, University of BolognaDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Radiology, Texas Children’s Hospital, Baylor College of MedicineDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pathology and Genomic Medicine, Houston Methodist HospitalDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pharmacy and Biotechnology, University of BolognaDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineDepartment of Pathology and Genomic Medicine, Houston Methodist HospitalDepartment of Pathology and Immunology, Baylor College of MedicineDepartment of Radiology, Texas Children’s Hospital, Baylor College of MedicineDan L Duncan Comprehensive Cancer Center, Baylor College of MedicineDepartment of Pharmacy and Biotechnology, University of BolognaDan L Duncan Comprehensive Cancer Center, Baylor College of MedicineDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children’s Cancer and Hematology Centers, Baylor College of MedicineHalf of high-risk neuroblastoma patients have MYCN amplification. Here, the authors show that MYCN induces fatty acid uptake and synthesis to support neuroblastoma and inhibition of a fatty acid transporter impairs tumor progression in preclinical models.https://doi.org/10.1038/s41467-022-31331-2 |
| spellingShingle | Ling Tao Mahmoud A. Mohammad Giorgio Milazzo Myrthala Moreno-Smith Tajhal D. Patel Barry Zorman Andrew Badachhape Blanca E. Hernandez Amber B. Wolf Zihua Zeng Jennifer H. Foster Sara Aloisi Pavel Sumazin Youli Zu John Hicks Ketan B. Ghaghada Nagireddy Putluri Giovanni Perini Cristian Coarfa Eveline Barbieri MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma Nature Communications |
| title | MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma |
| title_full | MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma |
| title_fullStr | MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma |
| title_full_unstemmed | MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma |
| title_short | MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma |
| title_sort | mycn driven fatty acid uptake is a metabolic vulnerability in neuroblastoma |
| url | https://doi.org/10.1038/s41467-022-31331-2 |
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