Particulate matter10-induced airway inflammation and fibrosis can be regulated by chitinase-1 suppression

Particulate matter10-induced airway inflammation and fibrosis can be regulated by chitinase-1 suppression

Abstract Background Particulate matter10 (PM10) can induce airway inflammation and fibrosis. Recently, chitinase-1 has been shown to play key roles in inflammation and fibrosis. We aimed to investigate the effects of chitinase-1 inhibitor in PM10-treated murine mice models. Methods In female BALB/c...

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Bibliographic Details
Main Authors: Yong Jun Choi, Heejae Han, Jae-Hyun Lee, Jaeuk Lee, Chi Young Kim, Min Kwang Byun, Jae Hwa Cho, Hye Jung Park
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Respiratory Research
Subjects:
Chitinase
Particulate matter
RNA sequencing
Lung
Online Access:https://doi.org/10.1186/s12931-023-02392-8

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