Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG Pathways
Nosocomial (hospital-acquired) infections remain a serious challenge for health systems. The reason for this lies not only in the local imperfection of medical practices and protocols. The frequency of infection with antibiotic-resistant strains of bacteria is growing every year, both in developed a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/21/7839 |
| _version_ | 1797550132677312512 |
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| author | Mikhail V. Slizen Oxana V. Galzitskaya |
| author_facet | Mikhail V. Slizen Oxana V. Galzitskaya |
| author_sort | Mikhail V. Slizen |
| collection | DOAJ |
| description | Nosocomial (hospital-acquired) infections remain a serious challenge for health systems. The reason for this lies not only in the local imperfection of medical practices and protocols. The frequency of infection with antibiotic-resistant strains of bacteria is growing every year, both in developed and developing countries. In this work, a pangenome and comparative analysis of 201 genomes of <i>Staphylococcus aureus</i>, <i>Enterobacter</i> spp., <i>Pseudomonas aeruginosa</i>, and <i>Mycoplasma</i> spp. was performed on the basis of high-level functional annotations—KEGG pathways and KEGG modules. The first three organisms are serious nosocomial pathogens, often exhibiting multidrug resistance. Analysis of KEGG modules revealed methicillin resistance in 25% of <i>S. aureus</i> strains and resistance to carbapenems in 21% of <i>Enterobacter</i> spp. strains. <i>P. aeruginosa</i> has a wide range of unique efflux systems. One hundred percent of the analyzed strains have at least two drug resistance systems, and 75% of the strains have seven. Each of the organisms has a characteristic set of metabolic features, whose impact on drug resistance can be considered in future studies. Comparing the genomes of nosocomial pathogens with each other and with <i>Mycoplasma</i> genomes can expand our understanding of the versatility of certain metabolic features and mechanisms of drug resistance. |
| first_indexed | 2024-03-10T15:25:10Z |
| format | Article |
| id | doaj.art-f4677a4d64e14d39815d3ef8df3a7d6e |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T15:25:10Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f4677a4d64e14d39815d3ef8df3a7d6e2023-11-20T18:10:46ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-012121783910.3390/ijms21217839Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG PathwaysMikhail V. Slizen0Oxana V. Galzitskaya1Institute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, RussiaInstitute of Protein Research, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, RussiaNosocomial (hospital-acquired) infections remain a serious challenge for health systems. The reason for this lies not only in the local imperfection of medical practices and protocols. The frequency of infection with antibiotic-resistant strains of bacteria is growing every year, both in developed and developing countries. In this work, a pangenome and comparative analysis of 201 genomes of <i>Staphylococcus aureus</i>, <i>Enterobacter</i> spp., <i>Pseudomonas aeruginosa</i>, and <i>Mycoplasma</i> spp. was performed on the basis of high-level functional annotations—KEGG pathways and KEGG modules. The first three organisms are serious nosocomial pathogens, often exhibiting multidrug resistance. Analysis of KEGG modules revealed methicillin resistance in 25% of <i>S. aureus</i> strains and resistance to carbapenems in 21% of <i>Enterobacter</i> spp. strains. <i>P. aeruginosa</i> has a wide range of unique efflux systems. One hundred percent of the analyzed strains have at least two drug resistance systems, and 75% of the strains have seven. Each of the organisms has a characteristic set of metabolic features, whose impact on drug resistance can be considered in future studies. Comparing the genomes of nosocomial pathogens with each other and with <i>Mycoplasma</i> genomes can expand our understanding of the versatility of certain metabolic features and mechanisms of drug resistance.https://www.mdpi.com/1422-0067/21/21/7839KEGG modulesKEGG pathwaysdrug resistance<i>Staphylococcus aureus</i><i>Enterobacter</i> spp.<i>Pseudomonas aeruginosa</i> |
| spellingShingle | Mikhail V. Slizen Oxana V. Galzitskaya Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG Pathways International Journal of Molecular Sciences KEGG modules KEGG pathways drug resistance <i>Staphylococcus aureus</i> <i>Enterobacter</i> spp. <i>Pseudomonas aeruginosa</i> |
| title | Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG Pathways |
| title_full | Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG Pathways |
| title_fullStr | Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG Pathways |
| title_full_unstemmed | Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG Pathways |
| title_short | Comparative Analysis of Proteomes of a Number of Nosocomial Pathogens by KEGG Modules and KEGG Pathways |
| title_sort | comparative analysis of proteomes of a number of nosocomial pathogens by kegg modules and kegg pathways |
| topic | KEGG modules KEGG pathways drug resistance <i>Staphylococcus aureus</i> <i>Enterobacter</i> spp. <i>Pseudomonas aeruginosa</i> |
| url | https://www.mdpi.com/1422-0067/21/21/7839 |
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