Bisphosphonate releasing dental implant surface coatings and osseointegration: A systematic review
Objectives: Bisphosphonates (BPs) are a class of drugs that are used to treat osteoporosis. It has been suggested that BP coatings on dental implants have a positive effect on new bone formation. The purpose of this review is to analyse the currently available data concerning the clinical and experi...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-10-01
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| Series: | Journal of Taibah University Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1658361217300896 |
| _version_ | 1818135033131565056 |
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| author | Shariq Najeeb, MSc Muhammad S. Zafar, PhD Zohaib Khurshid, MRes Sana Zohaib, MSc Syed M. Hasan, BDS Rabia S. Khan, MSc |
| author_facet | Shariq Najeeb, MSc Muhammad S. Zafar, PhD Zohaib Khurshid, MRes Sana Zohaib, MSc Syed M. Hasan, BDS Rabia S. Khan, MSc |
| author_sort | Shariq Najeeb, MSc |
| collection | DOAJ |
| description | Objectives: Bisphosphonates (BPs) are a class of drugs that are used to treat osteoporosis. It has been suggested that BP coatings on dental implants have a positive effect on new bone formation. The purpose of this review is to analyse the currently available data concerning the clinical and experimental efficacy of BP-releasing titanium implants such that their potential in clinical oral implant dentistry may be ascertained.
Methods: Based on a literature review, a focused research question was constructed: what is the effect of a BP-releasing coating on the osseointegration of titanium dental implant? The databases of PubMED/MEDLINE; ISI Web of Knowledge; Embase and Google Scholar were searched electronically using the keywords ‘dental implant’; ‘bisphosphonate’ and ‘titanium.’ The quality; general characteristics and outcomes of each study were summarized and analysed systematically.
Results: A total of eleven articles fulfilled the criteria to be included in this review. Eight studies were experimental; two studies were clinical; and one study was experimental and clinical. In nine studies (82%), BP-coated implants resulted in higher osseointegration, as indicated by higher resonance frequency values, removal torque, bone-implant contact and new bone formation. In two studies (18%), there was no difference between the osseointegration of BP-coated implants and controls.
Conclusions: Bisphosphonates-loaded implants may have a positive effect on osseointegration. However, more well-designed clinical studies are required to demonstrate their osseoconductive effects. |
| first_indexed | 2024-12-11T09:18:04Z |
| format | Article |
| id | doaj.art-f469113bc82b4ae2bf6a6ecf24323e36 |
| institution | Directory Open Access Journal |
| issn | 1658-3612 |
| language | English |
| last_indexed | 2024-12-11T09:18:04Z |
| publishDate | 2017-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Taibah University Medical Sciences |
| spelling | doaj.art-f469113bc82b4ae2bf6a6ecf24323e362022-12-22T01:13:20ZengElsevierJournal of Taibah University Medical Sciences1658-36122017-10-0112536937510.1016/j.jtumed.2017.05.007Bisphosphonate releasing dental implant surface coatings and osseointegration: A systematic reviewShariq Najeeb, MSc0Muhammad S. Zafar, PhD1Zohaib Khurshid, MRes2Sana Zohaib, MSc3Syed M. Hasan, BDS4Rabia S. Khan, MSc5Restorative Dental Sciences, Al-Farabi College, Al Khaleej, King Abdullah Road, Riyadh, KSADepartment of Restorative Dentistry, College of Dentistry, Taibah University, Almadinah Almunawwarah, KSADepartment of Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa, KSADepartment of Biomedical Engineering, King Faisal University, Al Hofuf, KSADepartment of Oral Medicine, Dow International Dental College, Dow University of Health Sciences, Karachi, PakistanDepartment of Oral Pathology, College of Dentistry, Baqai Medical University, Karachi, PakistanObjectives: Bisphosphonates (BPs) are a class of drugs that are used to treat osteoporosis. It has been suggested that BP coatings on dental implants have a positive effect on new bone formation. The purpose of this review is to analyse the currently available data concerning the clinical and experimental efficacy of BP-releasing titanium implants such that their potential in clinical oral implant dentistry may be ascertained. Methods: Based on a literature review, a focused research question was constructed: what is the effect of a BP-releasing coating on the osseointegration of titanium dental implant? The databases of PubMED/MEDLINE; ISI Web of Knowledge; Embase and Google Scholar were searched electronically using the keywords ‘dental implant’; ‘bisphosphonate’ and ‘titanium.’ The quality; general characteristics and outcomes of each study were summarized and analysed systematically. Results: A total of eleven articles fulfilled the criteria to be included in this review. Eight studies were experimental; two studies were clinical; and one study was experimental and clinical. In nine studies (82%), BP-coated implants resulted in higher osseointegration, as indicated by higher resonance frequency values, removal torque, bone-implant contact and new bone formation. In two studies (18%), there was no difference between the osseointegration of BP-coated implants and controls. Conclusions: Bisphosphonates-loaded implants may have a positive effect on osseointegration. However, more well-designed clinical studies are required to demonstrate their osseoconductive effects.http://www.sciencedirect.com/science/article/pii/S1658361217300896BisphosphonateDental biomaterialsDrug deliveryOsseointegration |
| spellingShingle | Shariq Najeeb, MSc Muhammad S. Zafar, PhD Zohaib Khurshid, MRes Sana Zohaib, MSc Syed M. Hasan, BDS Rabia S. Khan, MSc Bisphosphonate releasing dental implant surface coatings and osseointegration: A systematic review Journal of Taibah University Medical Sciences Bisphosphonate Dental biomaterials Drug delivery Osseointegration |
| title | Bisphosphonate releasing dental implant surface coatings and osseointegration: A systematic review |
| title_full | Bisphosphonate releasing dental implant surface coatings and osseointegration: A systematic review |
| title_fullStr | Bisphosphonate releasing dental implant surface coatings and osseointegration: A systematic review |
| title_full_unstemmed | Bisphosphonate releasing dental implant surface coatings and osseointegration: A systematic review |
| title_short | Bisphosphonate releasing dental implant surface coatings and osseointegration: A systematic review |
| title_sort | bisphosphonate releasing dental implant surface coatings and osseointegration a systematic review |
| topic | Bisphosphonate Dental biomaterials Drug delivery Osseointegration |
| url | http://www.sciencedirect.com/science/article/pii/S1658361217300896 |
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