TERRA INCOGNITA - CEREBELLAR CONTRIBUTIONS TO NEUROPSYCHIATRIC AND COGNITIVE DYSFUNCTION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA
Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioural variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00121/full |
| _version_ | 1818850847250972672 |
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| author | Rachel H Tan Rachel H Tan Emma eDevenney Emma eDevenney Matthew C Kiernan Matthew C Kiernan Glenda M Halliday Glenda M Halliday John R Hodges John R Hodges John R Hodges Michael eHornberger Michael eHornberger Michael eHornberger |
| author_facet | Rachel H Tan Rachel H Tan Emma eDevenney Emma eDevenney Matthew C Kiernan Matthew C Kiernan Glenda M Halliday Glenda M Halliday John R Hodges John R Hodges John R Hodges Michael eHornberger Michael eHornberger Michael eHornberger |
| author_sort | Rachel H Tan |
| collection | DOAJ |
| description | Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioural variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric deficits. The present study assessed whether degeneration in specific cerebellar subregions associate with indices of cognition and neuropsychiatric performance in bvFTD. Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function and motivation and the degree of grey matter degeneration in cerebellar lobules V-VII. Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD. Based on cortico-cerebellar connectivity maps, these findings in the cerebellum are consistent with the neural connections with the cortices involved in these domains in patients with bvFTD. Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD. |
| first_indexed | 2024-12-19T06:55:38Z |
| format | Article |
| id | doaj.art-f469608399b34bc5a18e0c127b768f4e |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-19T06:55:38Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-f469608399b34bc5a18e0c127b768f4e2022-12-21T20:31:33ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-07-01710.3389/fnagi.2015.00121144706TERRA INCOGNITA - CEREBELLAR CONTRIBUTIONS TO NEUROPSYCHIATRIC AND COGNITIVE DYSFUNCTION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIARachel H Tan0Rachel H Tan1Emma eDevenney2Emma eDevenney3Matthew C Kiernan4Matthew C Kiernan5Glenda M Halliday6Glenda M Halliday7John R Hodges8John R Hodges9John R Hodges10Michael eHornberger11Michael eHornberger12Michael eHornberger13Neuroscience Research AustraliaSchool of Medical Sciences, University of New South WalesNeuroscience Research AustraliaSchool of Medical Sciences, University of New South WalesNeuroscience Research AustraliaSydney Medical School, Brain and Mind Research Institute, University of SydneyNeuroscience Research AustraliaSchool of Medical Sciences, University of New South WalesNeuroscience Research AustraliaARC Centre of Excellence in Cognition and its Disorders, the University of New South Wales,School of Medical Sciences, University of New South WalesNeuroscience Research AustraliaDepartment of Clinical Neurosciences, Cambridge UniversityARC Centre of Excellence in Cognition and its Disorders, the University of New South Wales,Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioural variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric deficits. The present study assessed whether degeneration in specific cerebellar subregions associate with indices of cognition and neuropsychiatric performance in bvFTD. Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function and motivation and the degree of grey matter degeneration in cerebellar lobules V-VII. Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD. Based on cortico-cerebellar connectivity maps, these findings in the cerebellum are consistent with the neural connections with the cortices involved in these domains in patients with bvFTD. Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00121/fullCerebellumCognitionneural correlatesBehavioural variant frontotemporal dementiaNeuropsychiatric processes |
| spellingShingle | Rachel H Tan Rachel H Tan Emma eDevenney Emma eDevenney Matthew C Kiernan Matthew C Kiernan Glenda M Halliday Glenda M Halliday John R Hodges John R Hodges John R Hodges Michael eHornberger Michael eHornberger Michael eHornberger TERRA INCOGNITA - CEREBELLAR CONTRIBUTIONS TO NEUROPSYCHIATRIC AND COGNITIVE DYSFUNCTION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA Frontiers in Aging Neuroscience Cerebellum Cognition neural correlates Behavioural variant frontotemporal dementia Neuropsychiatric processes |
| title | TERRA INCOGNITA - CEREBELLAR CONTRIBUTIONS TO NEUROPSYCHIATRIC AND COGNITIVE DYSFUNCTION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA |
| title_full | TERRA INCOGNITA - CEREBELLAR CONTRIBUTIONS TO NEUROPSYCHIATRIC AND COGNITIVE DYSFUNCTION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA |
| title_fullStr | TERRA INCOGNITA - CEREBELLAR CONTRIBUTIONS TO NEUROPSYCHIATRIC AND COGNITIVE DYSFUNCTION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA |
| title_full_unstemmed | TERRA INCOGNITA - CEREBELLAR CONTRIBUTIONS TO NEUROPSYCHIATRIC AND COGNITIVE DYSFUNCTION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA |
| title_short | TERRA INCOGNITA - CEREBELLAR CONTRIBUTIONS TO NEUROPSYCHIATRIC AND COGNITIVE DYSFUNCTION IN BEHAVIOURAL VARIANT FRONTOTEMPORAL DEMENTIA |
| title_sort | terra incognita cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioural variant frontotemporal dementia |
| topic | Cerebellum Cognition neural correlates Behavioural variant frontotemporal dementia Neuropsychiatric processes |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00121/full |
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