Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort
To identify the characteristics of patients with sepsis or acute pyelonephritis (APN) combined with ureteral calculi and to analyze the risk factors in its causation. <b>Methods:</b> We included patients with sepsis or APN caused by ureteral calculi who received treatment in the United S...
| Hoofdauteurs: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formaat: | Artikel |
| Taal: | English |
| Gepubliceerd in: |
MDPI AG
2022-10-01
|
| Reeks: | Applied Sciences |
| Onderwerpen: | |
| Online toegang: | https://www.mdpi.com/2076-3417/12/21/10718 |
| _version_ | 1827647472259825664 |
|---|---|
| author | Francesco Del Giudice Koo Han Yoo Sinyeong Lee Jin Kyu Oh Hyuk Jin Cho Sang Youn Kim Gyeong Eun Min Sang Hyub Lee Wansuk Kim Shufeng Li Wuran Wei Jianlin Huang David R. Brown Kyle Spradling Satvir Basran Federico Belladelli Riccardo Autorino Savio Domenico Pandolfo Simone Crivellaro Felice Crocetto Matteo Ferro Vincenzo Asero Carlo Maria Scornajenghi Eugenio Bologna Alessandro Sciarra Stefano Salciccia Ettore De Berardinis Gian Piero Ricciuti Stefanie van Uem Simon Conti Benjamin I. Chung |
| author_facet | Francesco Del Giudice Koo Han Yoo Sinyeong Lee Jin Kyu Oh Hyuk Jin Cho Sang Youn Kim Gyeong Eun Min Sang Hyub Lee Wansuk Kim Shufeng Li Wuran Wei Jianlin Huang David R. Brown Kyle Spradling Satvir Basran Federico Belladelli Riccardo Autorino Savio Domenico Pandolfo Simone Crivellaro Felice Crocetto Matteo Ferro Vincenzo Asero Carlo Maria Scornajenghi Eugenio Bologna Alessandro Sciarra Stefano Salciccia Ettore De Berardinis Gian Piero Ricciuti Stefanie van Uem Simon Conti Benjamin I. Chung |
| author_sort | Francesco Del Giudice |
| collection | DOAJ |
| description | To identify the characteristics of patients with sepsis or acute pyelonephritis (APN) combined with ureteral calculi and to analyze the risk factors in its causation. <b>Methods:</b> We included patients with sepsis or APN caused by ureteral calculi who received treatment in the United States from January 2003 to December 2017 using the Optum® deidentified Clinformatics® Datamart. Demographic factors and risk factors for the receipt of sepsis or APN were subsequently analyzed for statistical significance. <b>Results:</b> Of 467,502 urinary stone patients, age-matched multivariate analysis revealed that a history of urinary tract infection (OR 11.31, 95% CI 10.68–11.99, <i>p</i> < 0.0001) and female gender (OR 2.73, 95% CI 2.62–2.84, <i>p</i> < 0.0001) were significantly related to an increased risk of sepsis or APN. Conversely, a previous past medical history of urolithiasis (OR 0.91, 95% CI 0.87–0.95, <i>p</i> < 0.0001) and cancer (OR 0.91, 95% CI 0.87–0.95, <i>p</i> < 0.0001) were associated with a decreased risk of sepsis or APN. With regards to comorbidities, when more than one comorbidity was present, there was an additive effect with higher OR point estimates, rising to 11.31 (10.68–11.99) when three or more comorbidities present. History of urinary tract infection and female gender are risk factors for sepsis or APN in patients with ureteral calculi. <b>Conclusions:</b> This large national cohort reveals the characteristics of sepsis or APN combined with ureteral stone and provides an important baseline for the treatment of urolithiasis in the future. |
| first_indexed | 2024-03-09T19:19:35Z |
| format | Article |
| id | doaj.art-f4699f1189e241569063b1df6dc9f56c |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T19:19:35Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-f4699f1189e241569063b1df6dc9f56c2023-11-24T03:31:41ZengMDPI AGApplied Sciences2076-34172022-10-0112211071810.3390/app122110718Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National CohortFrancesco Del Giudice0Koo Han Yoo1Sinyeong Lee2Jin Kyu Oh3Hyuk Jin Cho4Sang Youn Kim5Gyeong Eun Min6Sang Hyub Lee7Wansuk Kim8Shufeng Li9Wuran Wei10Jianlin Huang11David R. Brown12Kyle Spradling13Satvir Basran14Federico Belladelli15Riccardo Autorino16Savio Domenico Pandolfo17Simone Crivellaro18Felice Crocetto19Matteo Ferro20Vincenzo Asero21Carlo Maria Scornajenghi22Eugenio Bologna23Alessandro Sciarra24Stefano Salciccia25Ettore De Berardinis26Gian Piero Ricciuti27Stefanie van Uem28Simon Conti29Benjamin I. Chung30Department of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADivision of Urology, Virginia Commonwealth University, Richmond, VA 23284, USADivision of Urology, Virginia Commonwealth University, Richmond, VA 23284, USADepartment of Urology, University of Illinois Hospital & Health Sciences System, Chicago, IL 60613, USADepartment of Neuroscience and Reproductive and Odontostomatological Sciences, University Federico II, 80131 Naples, ItalyDivision of Urology, European Institute of Oncology-IRCCS, 20139 Milan, ItalyDepartment of Maternal Infant and Urologic Sciences, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal Infant and Urologic Sciences, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal Infant and Urologic Sciences, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal Infant and Urologic Sciences, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal Infant and Urologic Sciences, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal Infant and Urologic Sciences, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Maternal Infant and Urologic Sciences, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, ItalyDepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Urology, Stanford University School of Medicine, Stanford, CA 94305, USATo identify the characteristics of patients with sepsis or acute pyelonephritis (APN) combined with ureteral calculi and to analyze the risk factors in its causation. <b>Methods:</b> We included patients with sepsis or APN caused by ureteral calculi who received treatment in the United States from January 2003 to December 2017 using the Optum® deidentified Clinformatics® Datamart. Demographic factors and risk factors for the receipt of sepsis or APN were subsequently analyzed for statistical significance. <b>Results:</b> Of 467,502 urinary stone patients, age-matched multivariate analysis revealed that a history of urinary tract infection (OR 11.31, 95% CI 10.68–11.99, <i>p</i> < 0.0001) and female gender (OR 2.73, 95% CI 2.62–2.84, <i>p</i> < 0.0001) were significantly related to an increased risk of sepsis or APN. Conversely, a previous past medical history of urolithiasis (OR 0.91, 95% CI 0.87–0.95, <i>p</i> < 0.0001) and cancer (OR 0.91, 95% CI 0.87–0.95, <i>p</i> < 0.0001) were associated with a decreased risk of sepsis or APN. With regards to comorbidities, when more than one comorbidity was present, there was an additive effect with higher OR point estimates, rising to 11.31 (10.68–11.99) when three or more comorbidities present. History of urinary tract infection and female gender are risk factors for sepsis or APN in patients with ureteral calculi. <b>Conclusions:</b> This large national cohort reveals the characteristics of sepsis or APN combined with ureteral stone and provides an important baseline for the treatment of urolithiasis in the future.https://www.mdpi.com/2076-3417/12/21/10718sepsispyelonephritisureteral calculichronic disease |
| spellingShingle | Francesco Del Giudice Koo Han Yoo Sinyeong Lee Jin Kyu Oh Hyuk Jin Cho Sang Youn Kim Gyeong Eun Min Sang Hyub Lee Wansuk Kim Shufeng Li Wuran Wei Jianlin Huang David R. Brown Kyle Spradling Satvir Basran Federico Belladelli Riccardo Autorino Savio Domenico Pandolfo Simone Crivellaro Felice Crocetto Matteo Ferro Vincenzo Asero Carlo Maria Scornajenghi Eugenio Bologna Alessandro Sciarra Stefano Salciccia Ettore De Berardinis Gian Piero Ricciuti Stefanie van Uem Simon Conti Benjamin I. Chung Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort Applied Sciences sepsis pyelonephritis ureteral calculi chronic disease |
| title | Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort |
| title_full | Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort |
| title_fullStr | Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort |
| title_full_unstemmed | Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort |
| title_short | Characteristics of Sepsis or Acute Pyelonephritis Combined with Ureteral Stone in the United States: A Retrospective Analysis of Large National Cohort |
| title_sort | characteristics of sepsis or acute pyelonephritis combined with ureteral stone in the united states a retrospective analysis of large national cohort |
| topic | sepsis pyelonephritis ureteral calculi chronic disease |
| url | https://www.mdpi.com/2076-3417/12/21/10718 |
| work_keys_str_mv | AT francescodelgiudice characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT koohanyoo characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT sinyeonglee characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT jinkyuoh characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT hyukjincho characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT sangyounkim characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT gyeongeunmin characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT sanghyublee characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT wansukkim characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT shufengli characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT wuranwei characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT jianlinhuang characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT davidrbrown characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT kylespradling characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT satvirbasran characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT federicobelladelli characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT riccardoautorino characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT saviodomenicopandolfo characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT simonecrivellaro characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT felicecrocetto characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT matteoferro characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT vincenzoasero characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT carlomariascornajenghi characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT eugeniobologna characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT alessandrosciarra characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT stefanosalciccia characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT ettoredeberardinis characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT gianpieroricciuti characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT stefanievanuem characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT simonconti characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort AT benjaminichung characteristicsofsepsisoracutepyelonephritiscombinedwithureteralstoneintheunitedstatesaretrospectiveanalysisoflargenationalcohort |