Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety.
Novel pleuromutilin derivatives designed based on the structure of valnemulin were synthesized and evaluated for their in vitro antibacterial activities. These pleuromutilin derivatives with substituted amino moiety exhibited excellent activities against methicillin-resistant Staphylococcus aureus,...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3871055?pdf=render |
| _version_ | 1819050652337176576 |
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| author | Ruofeng Shang Shengyu Wang Ximing Xu Yunpeng Yi Wenzhu Guo Yuliu Jianping Liang |
| author_facet | Ruofeng Shang Shengyu Wang Ximing Xu Yunpeng Yi Wenzhu Guo Yuliu Jianping Liang |
| author_sort | Ruofeng Shang |
| collection | DOAJ |
| description | Novel pleuromutilin derivatives designed based on the structure of valnemulin were synthesized and evaluated for their in vitro antibacterial activities. These pleuromutilin derivatives with substituted amino moiety exhibited excellent activities against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae. Compound 5b showed the highest antibacterial activities and even exceeded tiamulin. Moreover, the docking experiments provided information about the binding model between the synthesized compounds and peptidyl transferase center (PTC) of 23S rRNA. |
| first_indexed | 2024-12-21T11:51:27Z |
| format | Article |
| id | doaj.art-f46b80de7ac0459aaf1c5070aa84eb3a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T11:51:27Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f46b80de7ac0459aaf1c5070aa84eb3a2022-12-21T19:05:03ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8259510.1371/journal.pone.0082595Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety.Ruofeng ShangShengyu WangXiming XuYunpeng YiWenzhu GuoYuliuJianping LiangNovel pleuromutilin derivatives designed based on the structure of valnemulin were synthesized and evaluated for their in vitro antibacterial activities. These pleuromutilin derivatives with substituted amino moiety exhibited excellent activities against methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, Escherichia coli, and Streptococcus agalactiae. Compound 5b showed the highest antibacterial activities and even exceeded tiamulin. Moreover, the docking experiments provided information about the binding model between the synthesized compounds and peptidyl transferase center (PTC) of 23S rRNA.http://europepmc.org/articles/PMC3871055?pdf=render |
| spellingShingle | Ruofeng Shang Shengyu Wang Ximing Xu Yunpeng Yi Wenzhu Guo Yuliu Jianping Liang Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety. PLoS ONE |
| title | Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety. |
| title_full | Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety. |
| title_fullStr | Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety. |
| title_full_unstemmed | Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety. |
| title_short | Chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety. |
| title_sort | chemical synthesis and biological activities of novel pleuromutilin derivatives with substituted amino moiety |
| url | http://europepmc.org/articles/PMC3871055?pdf=render |
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