Chromatin as a sensor of metabolic changes during early development
Cellular metabolism is a complex network of biochemical reactions fueling development with energy and biomass; however, it can also shape the cellular epigenome. Indeed, some intermediates of metabolic reactions exert a non-canonical function by acting as co-factors, substrates or inhibitors of chro...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1014498/full |
| _version_ | 1811194733085589504 |
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| author | David Pladevall-Morera Jan J. Zylicz |
| author_facet | David Pladevall-Morera Jan J. Zylicz |
| author_sort | David Pladevall-Morera |
| collection | DOAJ |
| description | Cellular metabolism is a complex network of biochemical reactions fueling development with energy and biomass; however, it can also shape the cellular epigenome. Indeed, some intermediates of metabolic reactions exert a non-canonical function by acting as co-factors, substrates or inhibitors of chromatin modifying enzymes. Therefore, fluctuating availability of such molecules has the potential to regulate the epigenetic landscape. Thanks to this functional coupling, chromatin can act as a sensor of metabolic changes and thus impact cell fate. Growing evidence suggest that both metabolic and epigenetic reprogramming are crucial for ensuring a successful embryo development from the zygote until gastrulation. In this review, we provide an overview of the complex relationship between metabolism and epigenetics in regulating the early stages of mammalian embryo development. We report on recent breakthroughs in uncovering the non-canonical functions of metabolism especially when re-localized to the nucleus. In addition, we identify the challenges and outline future perspectives to advance the novel field of epi-metabolomics especially in the context of early development. |
| first_indexed | 2024-04-12T00:31:31Z |
| format | Article |
| id | doaj.art-f46c8d5e82194953b1a99fdd7bc66748 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-12T00:31:31Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-f46c8d5e82194953b1a99fdd7bc667482022-12-22T03:55:20ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-10-011010.3389/fcell.2022.10144981014498Chromatin as a sensor of metabolic changes during early developmentDavid Pladevall-MoreraJan J. ZyliczCellular metabolism is a complex network of biochemical reactions fueling development with energy and biomass; however, it can also shape the cellular epigenome. Indeed, some intermediates of metabolic reactions exert a non-canonical function by acting as co-factors, substrates or inhibitors of chromatin modifying enzymes. Therefore, fluctuating availability of such molecules has the potential to regulate the epigenetic landscape. Thanks to this functional coupling, chromatin can act as a sensor of metabolic changes and thus impact cell fate. Growing evidence suggest that both metabolic and epigenetic reprogramming are crucial for ensuring a successful embryo development from the zygote until gastrulation. In this review, we provide an overview of the complex relationship between metabolism and epigenetics in regulating the early stages of mammalian embryo development. We report on recent breakthroughs in uncovering the non-canonical functions of metabolism especially when re-localized to the nucleus. In addition, we identify the challenges and outline future perspectives to advance the novel field of epi-metabolomics especially in the context of early development.https://www.frontiersin.org/articles/10.3389/fcell.2022.1014498/fullmetabolismepigeneticschromatincell fateepi-metabolomicsearly embryonic development |
| spellingShingle | David Pladevall-Morera Jan J. Zylicz Chromatin as a sensor of metabolic changes during early development Frontiers in Cell and Developmental Biology metabolism epigenetics chromatin cell fate epi-metabolomics early embryonic development |
| title | Chromatin as a sensor of metabolic changes during early development |
| title_full | Chromatin as a sensor of metabolic changes during early development |
| title_fullStr | Chromatin as a sensor of metabolic changes during early development |
| title_full_unstemmed | Chromatin as a sensor of metabolic changes during early development |
| title_short | Chromatin as a sensor of metabolic changes during early development |
| title_sort | chromatin as a sensor of metabolic changes during early development |
| topic | metabolism epigenetics chromatin cell fate epi-metabolomics early embryonic development |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1014498/full |
| work_keys_str_mv | AT davidpladevallmorera chromatinasasensorofmetabolicchangesduringearlydevelopment AT janjzylicz chromatinasasensorofmetabolicchangesduringearlydevelopment |