Assessment of Novel Proteins Triggering Celiac Disease via Docking-Based Approach

Assessment of Novel Proteins Triggering Celiac Disease via Docking-Based Approach

Human leukocyte antigens (HLAs) are pivotal in antigen processing, presenting to CD4+ T cells, and are linked to autoimmune disease susceptibility. In celiac disease, HLA-DQ2.5 and HLA-DQ8.1 bind gluten peptides on APCs, some recognized by CD4+ T cells, prompting inflammation and tissue damage. Whil...

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Bibliographic Details
Main Authors: Mariyana Atanasova, Ivan Dimitrov, Antonio Fernandez, Javier Moreno, Frits Koning, Irini Doytchinova
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Molecules
Subjects:
celiac disease
HLA-DQ2.5
HLA-DQ8.1
molecular docking
quantitative matrix
peptide binding prediction
Online Access:https://www.mdpi.com/1420-3049/29/1/138

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