Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update
The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (GM) produce neuroactives, specifically neurotransm...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1324018/full |
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| author | Tousif Ahmed Hediyal Tousif Ahmed Hediyal C. Vichitra C. Vichitra Nikhilesh Anand Mahendran Bhaskaran Saeefh M. Essa Pravir Kumar M. Walid Qoronfleh Mohammed Akbar Ruchika Kaul-Ghanekar Arehally M. Mahalakshmi Arehally M. Mahalakshmi Jian Yang Byoung-Joon Song Tanya M. Monaghan Tanya M. Monaghan Meena Kishore Sakharkar Saravana Babu Chidambaram Saravana Babu Chidambaram |
| author_facet | Tousif Ahmed Hediyal Tousif Ahmed Hediyal C. Vichitra C. Vichitra Nikhilesh Anand Mahendran Bhaskaran Saeefh M. Essa Pravir Kumar M. Walid Qoronfleh Mohammed Akbar Ruchika Kaul-Ghanekar Arehally M. Mahalakshmi Arehally M. Mahalakshmi Jian Yang Byoung-Joon Song Tanya M. Monaghan Tanya M. Monaghan Meena Kishore Sakharkar Saravana Babu Chidambaram Saravana Babu Chidambaram |
| author_sort | Tousif Ahmed Hediyal |
| collection | DOAJ |
| description | The bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (GM) produce neuroactives, specifically neurotransmitters that modulates local and central neuronal brain functions. An imbalance between intestinal commensals and pathobionts leads to a disruption in the gut microbiota or dysbiosis, which affects intestinal barrier integrity and gut-immune and neuroimmune systems. Currently, fecal microbiota transplantation (FMT) is recommended for the treatment of recurrent Clostridioides difficile infection. FMT elicits its action by ameliorating inflammatory responses through the restoration of microbial composition and functionality. Thus, FMT may be a potential therapeutic option in suppressing neuroinflammation in post-stroke conditions and other neurological disorders involving the neuroimmune axis. Specifically, FMT protects against ischemic injury by decreasing IL-17, IFN-γ, Bax, and increasing Bcl-2 expression. Interestingly, FMT improves cognitive function by lowering amyloid-β accumulation and upregulating synaptic marker (PSD-95, synapsin-1) expression in Alzheimer’s disease. In Parkinson’s disease, FMT was shown to inhibit the expression of TLR4 and NF-κB. In this review article, we have summarized the potential sources and methods of administration of FMT and its impact on neuroimmune and cognitive functions. We also provide a comprehensive update on the beneficial effects of FMT in various neurological disorders by undertaking a detailed interrogation of the preclinical and clinical published literature. |
| first_indexed | 2024-03-07T23:21:25Z |
| format | Article |
| id | doaj.art-f46ea6f3e6bd42d480f3ee9661e9c49e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T23:21:25Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-f46ea6f3e6bd42d480f3ee9661e9c49e2024-02-21T05:50:36ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13240181324018Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an updateTousif Ahmed Hediyal0Tousif Ahmed Hediyal1C. Vichitra2C. Vichitra3Nikhilesh Anand4Mahendran Bhaskaran5Saeefh M. Essa6Pravir Kumar7M. Walid Qoronfleh8Mohammed Akbar9Ruchika Kaul-Ghanekar10Arehally M. Mahalakshmi11Arehally M. Mahalakshmi12Jian Yang13Byoung-Joon Song14Tanya M. Monaghan15Tanya M. Monaghan16Meena Kishore Sakharkar17Saravana Babu Chidambaram18Saravana Babu Chidambaram19Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, KA, IndiaCentre for Experimental Pharmacology and Toxicology, JSS Academy of Higher Education & Research, Mysuru, KA, IndiaDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, KA, IndiaCentre for Experimental Pharmacology and Toxicology, JSS Academy of Higher Education & Research, Mysuru, KA, IndiaDepartment of Pharmacology, American University of Antigua, College of Medicine, Saint John’s, Antigua and BarbudaCollege of Pharmacy and Pharmaceutical Sciences, Frederic and Mary Wolf Centre University of Toledo, Health Science, Toledo, OH, United StatesDepartment of Computer Science, Northwest High School, Bethesda, MD, United StatesMolecular Neuroscience and Functional Genomics Laboratory, Department of Biotechnology, Delhi Technological University (Formerly DCE), Delhi, IndiaQ3CG Research Institute (QRI), Research and Policy Division, Ypsilanti, MI, United StatesDivision of Neuroscience and Behavior, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, United StatesSymbiosis Centre for Research and Innovation (SCRI), Cancer Research Lab, Symbiosis School of Biological Sciences (SSBS), Symbiosis International University (SIU), Pune, Maharashtra, IndiaDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, KA, IndiaCentre for Experimental Pharmacology and Toxicology, JSS Academy of Higher Education & Research, Mysuru, KA, India0Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada1Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Bio-physics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, United States2National Institute for Health Research Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom3Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom0Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, CanadaDepartment of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, KA, IndiaCentre for Experimental Pharmacology and Toxicology, JSS Academy of Higher Education & Research, Mysuru, KA, IndiaThe bidirectional communication between the gut and brain or gut-brain axis is regulated by several gut microbes and microbial derived metabolites, such as short-chain fatty acids, trimethylamine N-oxide, and lipopolysaccharides. The Gut microbiota (GM) produce neuroactives, specifically neurotransmitters that modulates local and central neuronal brain functions. An imbalance between intestinal commensals and pathobionts leads to a disruption in the gut microbiota or dysbiosis, which affects intestinal barrier integrity and gut-immune and neuroimmune systems. Currently, fecal microbiota transplantation (FMT) is recommended for the treatment of recurrent Clostridioides difficile infection. FMT elicits its action by ameliorating inflammatory responses through the restoration of microbial composition and functionality. Thus, FMT may be a potential therapeutic option in suppressing neuroinflammation in post-stroke conditions and other neurological disorders involving the neuroimmune axis. Specifically, FMT protects against ischemic injury by decreasing IL-17, IFN-γ, Bax, and increasing Bcl-2 expression. Interestingly, FMT improves cognitive function by lowering amyloid-β accumulation and upregulating synaptic marker (PSD-95, synapsin-1) expression in Alzheimer’s disease. In Parkinson’s disease, FMT was shown to inhibit the expression of TLR4 and NF-κB. In this review article, we have summarized the potential sources and methods of administration of FMT and its impact on neuroimmune and cognitive functions. We also provide a comprehensive update on the beneficial effects of FMT in various neurological disorders by undertaking a detailed interrogation of the preclinical and clinical published literature.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1324018/fullgut microbiotagut-brain axisimmune cellsneuroimmune axisneuroinflammationfecal microbiota transplantation |
| spellingShingle | Tousif Ahmed Hediyal Tousif Ahmed Hediyal C. Vichitra C. Vichitra Nikhilesh Anand Mahendran Bhaskaran Saeefh M. Essa Pravir Kumar M. Walid Qoronfleh Mohammed Akbar Ruchika Kaul-Ghanekar Arehally M. Mahalakshmi Arehally M. Mahalakshmi Jian Yang Byoung-Joon Song Tanya M. Monaghan Tanya M. Monaghan Meena Kishore Sakharkar Saravana Babu Chidambaram Saravana Babu Chidambaram Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update Frontiers in Immunology gut microbiota gut-brain axis immune cells neuroimmune axis neuroinflammation fecal microbiota transplantation |
| title | Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update |
| title_full | Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update |
| title_fullStr | Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update |
| title_full_unstemmed | Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update |
| title_short | Protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders: an update |
| title_sort | protective effects of fecal microbiota transplantation against ischemic stroke and other neurological disorders an update |
| topic | gut microbiota gut-brain axis immune cells neuroimmune axis neuroinflammation fecal microbiota transplantation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1324018/full |
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