COVID-19-associated mucormycosis: Preliminary report from a tertiary eye care centre
Purpose: Mucormycosis is a life-threatening infection that has made sudden comeback in COVID-19 era. We conducted this study to determine demography, site of involvement, management, and outcome in these patients. Methods: All cases presenting with signs and symptoms of mucormycosis were thoroughly...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=12;spage=3685;epage=3689;aulast=Walia |
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| author | Shweta Walia Vijay Bhaisare Preeti Rawat Neetu Kori Manushree Sharma Niti Gupta Shishir Urdhwareshwar Sanchiyka Thakur Niharika Arya |
| author_facet | Shweta Walia Vijay Bhaisare Preeti Rawat Neetu Kori Manushree Sharma Niti Gupta Shishir Urdhwareshwar Sanchiyka Thakur Niharika Arya |
| author_sort | Shweta Walia |
| collection | DOAJ |
| description | Purpose: Mucormycosis is a life-threatening infection that has made sudden comeback in COVID-19 era. We conducted this study to determine demography, site of involvement, management, and outcome in these patients. Methods: All cases presenting with signs and symptoms of mucormycosis were thoroughly evaluated and confirmed diagnosis was made on demonstration of fungi in the tissue (or body fluids) either by direct microscopy and/or culture. Patients underwent computerized tomography scan for paranasal sinuses and magnetic resonance imaging scan with contrast orbit and brain to know extent of disease. Results: 540 proven cases of mucormycosis were included. Most common age group affected was 41–50 years with male preponderance (69%). Sinonasal was the most common site of involvement in mucormycosis (100%), followed by orbital (51.85%), cerebral (9.44%), cutaneous (1.85%), and pulmonary (0.18%). Most common presentation was periocular and facial swelling (28%). 97.96% patients had associated diabetes and 89.44% patients had history of COVID-19 with concurrent steroids use (84.85%), higher antibiotics (82.59%), oxygen therapy (52.40%), remdesivir (28.89%), and biological agents (2.56%). Duration from COVID-19 positivity to presentation of mucormycosis was 22.56 days, while 4.44% patients had coexisting COVID-19 with mucormycosis. The mortality rate was 9.25% (50/540). Conclusion: Timely diagnosis and appropriate management can ameliorate the consequences of mucormycosis. With the third wave of COVID-19 coming, epidemiological study to identify risk factors and possible management options can help physicians to develop the treatment strategy. |
| first_indexed | 2024-04-11T17:00:46Z |
| format | Article |
| id | doaj.art-f470b15265c946468a5650669610826d |
| institution | Directory Open Access Journal |
| issn | 0301-4738 1998-3689 |
| language | English |
| last_indexed | 2024-04-11T17:00:46Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-f470b15265c946468a5650669610826d2022-12-22T04:13:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892021-01-0169123685368910.4103/ijo.IJO_2085_21COVID-19-associated mucormycosis: Preliminary report from a tertiary eye care centreShweta WaliaVijay BhaisarePreeti RawatNeetu KoriManushree SharmaNiti GuptaShishir UrdhwareshwarSanchiyka ThakurNiharika AryaPurpose: Mucormycosis is a life-threatening infection that has made sudden comeback in COVID-19 era. We conducted this study to determine demography, site of involvement, management, and outcome in these patients. Methods: All cases presenting with signs and symptoms of mucormycosis were thoroughly evaluated and confirmed diagnosis was made on demonstration of fungi in the tissue (or body fluids) either by direct microscopy and/or culture. Patients underwent computerized tomography scan for paranasal sinuses and magnetic resonance imaging scan with contrast orbit and brain to know extent of disease. Results: 540 proven cases of mucormycosis were included. Most common age group affected was 41–50 years with male preponderance (69%). Sinonasal was the most common site of involvement in mucormycosis (100%), followed by orbital (51.85%), cerebral (9.44%), cutaneous (1.85%), and pulmonary (0.18%). Most common presentation was periocular and facial swelling (28%). 97.96% patients had associated diabetes and 89.44% patients had history of COVID-19 with concurrent steroids use (84.85%), higher antibiotics (82.59%), oxygen therapy (52.40%), remdesivir (28.89%), and biological agents (2.56%). Duration from COVID-19 positivity to presentation of mucormycosis was 22.56 days, while 4.44% patients had coexisting COVID-19 with mucormycosis. The mortality rate was 9.25% (50/540). Conclusion: Timely diagnosis and appropriate management can ameliorate the consequences of mucormycosis. With the third wave of COVID-19 coming, epidemiological study to identify risk factors and possible management options can help physicians to develop the treatment strategy.http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=12;spage=3685;epage=3689;aulast=Waliaamphotericin bcovid-19 (coronavirus disease in 2019)diabetes mellitusimmunosuppressionmucoralesmucormycetesmucormycosis |
| spellingShingle | Shweta Walia Vijay Bhaisare Preeti Rawat Neetu Kori Manushree Sharma Niti Gupta Shishir Urdhwareshwar Sanchiyka Thakur Niharika Arya COVID-19-associated mucormycosis: Preliminary report from a tertiary eye care centre Indian Journal of Ophthalmology amphotericin b covid-19 (coronavirus disease in 2019) diabetes mellitus immunosuppression mucorales mucormycetes mucormycosis |
| title | COVID-19-associated mucormycosis: Preliminary report from a tertiary eye care centre |
| title_full | COVID-19-associated mucormycosis: Preliminary report from a tertiary eye care centre |
| title_fullStr | COVID-19-associated mucormycosis: Preliminary report from a tertiary eye care centre |
| title_full_unstemmed | COVID-19-associated mucormycosis: Preliminary report from a tertiary eye care centre |
| title_short | COVID-19-associated mucormycosis: Preliminary report from a tertiary eye care centre |
| title_sort | covid 19 associated mucormycosis preliminary report from a tertiary eye care centre |
| topic | amphotericin b covid-19 (coronavirus disease in 2019) diabetes mellitus immunosuppression mucorales mucormycetes mucormycosis |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2021;volume=69;issue=12;spage=3685;epage=3689;aulast=Walia |
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