The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection
The SARS-CoV-2 virus was reported for the first time in Wuhan, Hubei Province, China, and causes respiratory infection. This pandemic pneumonia killed about 1,437,835 people out of 61,308,161cases up to November 27, 2020. The disease’s main clinical complications include fever, recurrent coughing, s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.616993/full |
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| author | Mohammad Reza Kalhori Fatemeh Saadatpour Ehsan Arefian Masoud Soleimani Mohammad Hosien Farzaei Ina Yosifova Aneva Javier Echeverría |
| author_facet | Mohammad Reza Kalhori Fatemeh Saadatpour Ehsan Arefian Masoud Soleimani Mohammad Hosien Farzaei Ina Yosifova Aneva Javier Echeverría |
| author_sort | Mohammad Reza Kalhori |
| collection | DOAJ |
| description | The SARS-CoV-2 virus was reported for the first time in Wuhan, Hubei Province, China, and causes respiratory infection. This pandemic pneumonia killed about 1,437,835 people out of 61,308,161cases up to November 27, 2020. The disease’s main clinical complications include fever, recurrent coughing, shortness of breath, acute respiratory syndrome, and failure of vital organs that could lead to death. It has been shown that natural compounds with antioxidant, anticancer, and antiviral activities and RNA interference agents could play an essential role in preventing or treating coronavirus infection by inhibiting the expression of crucial virus genes. This study aims to introduce a summary of coronavirus’s genetic and morphological structure and determine the role of miRNAs, siRNAs, chemical drugs, and natural compounds in stimulating the immune system or inhibiting the virus’s structural and non-structural genes that are essential for replication and infection of SARS-CoV-2. |
| first_indexed | 2024-12-14T17:53:53Z |
| format | Article |
| id | doaj.art-f470c2d6ef1246a596e710bbd3a9d610 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-14T17:53:53Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-f470c2d6ef1246a596e710bbd3a9d6102022-12-21T22:52:35ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-02-011210.3389/fphar.2021.616993616993The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses InfectionMohammad Reza Kalhori0Fatemeh Saadatpour1Ehsan Arefian2Masoud Soleimani3Mohammad Hosien Farzaei4Ina Yosifova Aneva5Javier Echeverría6Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranMolecular Virology Lab, Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, IranMolecular Virology Lab, Department of Microbiology, School of Biology, College of Science, University of Tehran, Tehran, IranDepartment of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, IranMedical Technology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, IranInstitute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia, BulgariaDepartamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, ChileThe SARS-CoV-2 virus was reported for the first time in Wuhan, Hubei Province, China, and causes respiratory infection. This pandemic pneumonia killed about 1,437,835 people out of 61,308,161cases up to November 27, 2020. The disease’s main clinical complications include fever, recurrent coughing, shortness of breath, acute respiratory syndrome, and failure of vital organs that could lead to death. It has been shown that natural compounds with antioxidant, anticancer, and antiviral activities and RNA interference agents could play an essential role in preventing or treating coronavirus infection by inhibiting the expression of crucial virus genes. This study aims to introduce a summary of coronavirus’s genetic and morphological structure and determine the role of miRNAs, siRNAs, chemical drugs, and natural compounds in stimulating the immune system or inhibiting the virus’s structural and non-structural genes that are essential for replication and infection of SARS-CoV-2.https://www.frontiersin.org/articles/10.3389/fphar.2021.616993/fullcoronavirusmiRNAsiRNAnatural productsphytochemicalsSARS-CoV-2 |
| spellingShingle | Mohammad Reza Kalhori Fatemeh Saadatpour Ehsan Arefian Masoud Soleimani Mohammad Hosien Farzaei Ina Yosifova Aneva Javier Echeverría The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection Frontiers in Pharmacology coronavirus miRNA siRNA natural products phytochemicals SARS-CoV-2 |
| title | The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection |
| title_full | The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection |
| title_fullStr | The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection |
| title_full_unstemmed | The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection |
| title_short | The Potential Therapeutic Effect of RNA Interference and Natural Products on COVID-19: A Review of the Coronaviruses Infection |
| title_sort | potential therapeutic effect of rna interference and natural products on covid 19 a review of the coronaviruses infection |
| topic | coronavirus miRNA siRNA natural products phytochemicals SARS-CoV-2 |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.616993/full |
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