Low Plasma Levels of Irisin Predict Acutely Decompensated Heart Failure in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure
The aim of this study was to determine the discriminative value of irisin for acutely decompensated heart failure (ADHF) in type 2 diabetes mellitus (T2DM) patients with chronic HF. We included 480 T2DM patients with any phenotype of HF and followed them for 52 weeks. Hemodynamic performances and th...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-03-01
|
| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/10/4/136 |
| _version_ | 1797604981864398848 |
|---|---|
| author | Alexander A. Berezin Anica Babic Obradovic Ivan M. Fushtey Tetiana A Berezina Michael Lichtenauer Alexander E Berezin |
| author_facet | Alexander A. Berezin Anica Babic Obradovic Ivan M. Fushtey Tetiana A Berezina Michael Lichtenauer Alexander E Berezin |
| author_sort | Alexander A. Berezin |
| collection | DOAJ |
| description | The aim of this study was to determine the discriminative value of irisin for acutely decompensated heart failure (ADHF) in type 2 diabetes mellitus (T2DM) patients with chronic HF. We included 480 T2DM patients with any phenotype of HF and followed them for 52 weeks. Hemodynamic performances and the serum levels of biomarkers were detected at the study entry. The primary clinical end-point was ADHF that led to urgent hospitalization. We found that the serum levels of N-terminal natriuretic pro-peptide (NT-proBNP) were higher (1719 [980–2457] pmol/mL vs. 1057 [570–2607] pmol/mL, respectively) and the levels of irisin were lower (4.96 [3.14–6.85] ng/mL vs. 7.95 [5.73–9.16] ng/mL) in ADHF patients than in those without ADHF. The ROC curve analysis showed that the estimated cut-off point for serum irisin levels (ADHF versus non-ADHF) was 7.85 ng/mL (area under curve [AUC] = 0.869 (95% CI = 0.800–0.937), sensitivity = 82.7%, specificity = 73.5%; <i>p</i> = 0.0001). The multivariate logistic regression yielded that the serum levels of irisin < 7.85 ng/mL (OR = 1.20; <i>p</i> = 0.001) and NT-proBNP > 1215 pmol/mL (OR = 1.18; <i>p</i> = 0.001) retained the predictors for ADHF. Kaplan–Meier plots showed a significant difference of clinical end-point accumulations in patients with HF depending on irisin levels (<7.85 ng/mL versus ≥7.85 ng/mL). In conclusion, we established that decreased levels of irisin were associated with ADHF presentation in chronic HF patients with T2DM independently from NT-proBNP. |
| first_indexed | 2024-03-11T04:54:34Z |
| format | Article |
| id | doaj.art-f47290f19df443bdbdc67c3a3c08bcea |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-11T04:54:34Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-f47290f19df443bdbdc67c3a3c08bcea2023-11-17T19:47:19ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252023-03-0110413610.3390/jcdd10040136Low Plasma Levels of Irisin Predict Acutely Decompensated Heart Failure in Type 2 Diabetes Mellitus Patients with Chronic Heart FailureAlexander A. Berezin0Anica Babic Obradovic1Ivan M. Fushtey2Tetiana A Berezina3Michael Lichtenauer4Alexander E Berezin5Department of Internal Medicine, Zaporozhye Medical Academy of Postgraduate Education, 69096 Zaporozhye, UkraineMedical Practice for General Medicine, 22111 Hamburg, GermanyDepartment of Internal Medicine, Zaporozhye Medical Academy of Postgraduate Education, 69096 Zaporozhye, UkraineVita Center, Department of Internal Medicine and Nephrology, 69000 Zaporozhye, UkraineDivision of Cardiology, Department of Internal Medicine II, Paracelsus Medical University, 5020 Salzburg, AustriaDivision of Cardiology, Department of Internal Medicine II, Paracelsus Medical University, 5020 Salzburg, AustriaThe aim of this study was to determine the discriminative value of irisin for acutely decompensated heart failure (ADHF) in type 2 diabetes mellitus (T2DM) patients with chronic HF. We included 480 T2DM patients with any phenotype of HF and followed them for 52 weeks. Hemodynamic performances and the serum levels of biomarkers were detected at the study entry. The primary clinical end-point was ADHF that led to urgent hospitalization. We found that the serum levels of N-terminal natriuretic pro-peptide (NT-proBNP) were higher (1719 [980–2457] pmol/mL vs. 1057 [570–2607] pmol/mL, respectively) and the levels of irisin were lower (4.96 [3.14–6.85] ng/mL vs. 7.95 [5.73–9.16] ng/mL) in ADHF patients than in those without ADHF. The ROC curve analysis showed that the estimated cut-off point for serum irisin levels (ADHF versus non-ADHF) was 7.85 ng/mL (area under curve [AUC] = 0.869 (95% CI = 0.800–0.937), sensitivity = 82.7%, specificity = 73.5%; <i>p</i> = 0.0001). The multivariate logistic regression yielded that the serum levels of irisin < 7.85 ng/mL (OR = 1.20; <i>p</i> = 0.001) and NT-proBNP > 1215 pmol/mL (OR = 1.18; <i>p</i> = 0.001) retained the predictors for ADHF. Kaplan–Meier plots showed a significant difference of clinical end-point accumulations in patients with HF depending on irisin levels (<7.85 ng/mL versus ≥7.85 ng/mL). In conclusion, we established that decreased levels of irisin were associated with ADHF presentation in chronic HF patients with T2DM independently from NT-proBNP.https://www.mdpi.com/2308-3425/10/4/136acutely decompensated heart failurechronic heart failuretype 2 diabetes mellitusirisinnatriuretic peptidescardiac remodeling |
| spellingShingle | Alexander A. Berezin Anica Babic Obradovic Ivan M. Fushtey Tetiana A Berezina Michael Lichtenauer Alexander E Berezin Low Plasma Levels of Irisin Predict Acutely Decompensated Heart Failure in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure Journal of Cardiovascular Development and Disease acutely decompensated heart failure chronic heart failure type 2 diabetes mellitus irisin natriuretic peptides cardiac remodeling |
| title | Low Plasma Levels of Irisin Predict Acutely Decompensated Heart Failure in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure |
| title_full | Low Plasma Levels of Irisin Predict Acutely Decompensated Heart Failure in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure |
| title_fullStr | Low Plasma Levels of Irisin Predict Acutely Decompensated Heart Failure in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure |
| title_full_unstemmed | Low Plasma Levels of Irisin Predict Acutely Decompensated Heart Failure in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure |
| title_short | Low Plasma Levels of Irisin Predict Acutely Decompensated Heart Failure in Type 2 Diabetes Mellitus Patients with Chronic Heart Failure |
| title_sort | low plasma levels of irisin predict acutely decompensated heart failure in type 2 diabetes mellitus patients with chronic heart failure |
| topic | acutely decompensated heart failure chronic heart failure type 2 diabetes mellitus irisin natriuretic peptides cardiac remodeling |
| url | https://www.mdpi.com/2308-3425/10/4/136 |
| work_keys_str_mv | AT alexanderaberezin lowplasmalevelsofirisinpredictacutelydecompensatedheartfailureintype2diabetesmellituspatientswithchronicheartfailure AT anicababicobradovic lowplasmalevelsofirisinpredictacutelydecompensatedheartfailureintype2diabetesmellituspatientswithchronicheartfailure AT ivanmfushtey lowplasmalevelsofirisinpredictacutelydecompensatedheartfailureintype2diabetesmellituspatientswithchronicheartfailure AT tetianaaberezina lowplasmalevelsofirisinpredictacutelydecompensatedheartfailureintype2diabetesmellituspatientswithchronicheartfailure AT michaellichtenauer lowplasmalevelsofirisinpredictacutelydecompensatedheartfailureintype2diabetesmellituspatientswithchronicheartfailure AT alexandereberezin lowplasmalevelsofirisinpredictacutelydecompensatedheartfailureintype2diabetesmellituspatientswithchronicheartfailure |