Pancreatitis and Pancreatic Cancer Risk
Purpose: The present retrospective study aimed to explore the relationship between pancreatitis and pancreatic cancer in the population cohort of the UK Biobank (UKB) ( https://www.ukbiobank.ac.uk ). Methods: From the 500 thousand population cohort of UKB, according to the age and gender of patients...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-03-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338231164875 |
| _version_ | 1797689843568869376 |
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| author | Dong-Mei Ma MD Xiao-Wu Dong PhD Xiao Han MS Zhi Ling MS Guo-Tao Lu PhD Yun-Yun Sun PhD Xu-Dong Yin PhD |
| author_facet | Dong-Mei Ma MD Xiao-Wu Dong PhD Xiao Han MS Zhi Ling MS Guo-Tao Lu PhD Yun-Yun Sun PhD Xu-Dong Yin PhD |
| author_sort | Dong-Mei Ma MD |
| collection | DOAJ |
| description | Purpose: The present retrospective study aimed to explore the relationship between pancreatitis and pancreatic cancer in the population cohort of the UK Biobank (UKB) ( https://www.ukbiobank.ac.uk ). Methods: From the 500 thousand population cohort of UKB, according to the age and gender of patients with pancreatic cancer 1:10, matching the control without pancreatic cancer, the binary Logistic regression model was used to analyze the relationship between pancreatitis and pancreatic cancer, and subgroup analyses were used to identify potential effect modifiers. Results: A total of 1538 patients with pancreatic cancer were compared with 15 380 controls. In the fully adjusted model, patients with pancreatitis had a significantly increased risk of pancreatic cancer compared with no pancreatitis. The risk of pancreatitis and pancreatic cancer increased with the age of pancreatitis, and the risk of pancreatic cancer was highest in the 61 to 70 age group. In addition, in the first 3 years of acute pancreatitis, the risk of pancreatic cancer increased significantly with the increase in the duration of the disease (odds ratio [OR] 29.13, 95% confidence interval [CI]: 16.34-51.93), after 3 years, the trend of increase decreased. After more than 10 years, there was no significant correlation between the risk of acute pancreatitis and pancreatic cancer. However, patients with chronic pancreatitis were significantly associated with an increased risk of pancreatic cancer only in the first 3 years (OR 28.14, 95% CI: 14.86-53.31). Conclusion: Pancreatitis may associate with an increased risk of pancreatic cancer. The older the age of pancreatitis, the higher the risk of pancreatic cancer. The risk of pancreatic cancer increases significantly in the first 3 years of the course of pancreatitis. This may provide an alternative strategy for the early identification of individuals at high risk of pancreatic cancer. |
| first_indexed | 2024-03-12T01:51:52Z |
| format | Article |
| id | doaj.art-f473a5ffd7184f1a9fd65b0fc7dbb52c |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-03-12T01:51:52Z |
| publishDate | 2023-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-f473a5ffd7184f1a9fd65b0fc7dbb52c2023-09-08T12:33:34ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382023-03-012210.1177/15330338231164875Pancreatitis and Pancreatic Cancer RiskDong-Mei Ma MD0Xiao-Wu Dong PhD1Xiao Han MS2Zhi Ling MS3Guo-Tao Lu PhD4Yun-Yun Sun PhD5Xu-Dong Yin PhD6 Department of Oncology, , Yangzhou University, Yangzhou, China Yangzhou Key Laboratory of Pancreatic Diseases, Yangzhou, China Department of Oncology, , Yangzhou University, Yangzhou, China Department of Oncology, , Yangzhou University, Yangzhou, China Yangzhou Key Laboratory of Pancreatic Diseases, Yangzhou, China Yangzhou Key Laboratory of Pancreatic Diseases, Yangzhou, China Department of Oncology, , Yangzhou University, Yangzhou, ChinaPurpose: The present retrospective study aimed to explore the relationship between pancreatitis and pancreatic cancer in the population cohort of the UK Biobank (UKB) ( https://www.ukbiobank.ac.uk ). Methods: From the 500 thousand population cohort of UKB, according to the age and gender of patients with pancreatic cancer 1:10, matching the control without pancreatic cancer, the binary Logistic regression model was used to analyze the relationship between pancreatitis and pancreatic cancer, and subgroup analyses were used to identify potential effect modifiers. Results: A total of 1538 patients with pancreatic cancer were compared with 15 380 controls. In the fully adjusted model, patients with pancreatitis had a significantly increased risk of pancreatic cancer compared with no pancreatitis. The risk of pancreatitis and pancreatic cancer increased with the age of pancreatitis, and the risk of pancreatic cancer was highest in the 61 to 70 age group. In addition, in the first 3 years of acute pancreatitis, the risk of pancreatic cancer increased significantly with the increase in the duration of the disease (odds ratio [OR] 29.13, 95% confidence interval [CI]: 16.34-51.93), after 3 years, the trend of increase decreased. After more than 10 years, there was no significant correlation between the risk of acute pancreatitis and pancreatic cancer. However, patients with chronic pancreatitis were significantly associated with an increased risk of pancreatic cancer only in the first 3 years (OR 28.14, 95% CI: 14.86-53.31). Conclusion: Pancreatitis may associate with an increased risk of pancreatic cancer. The older the age of pancreatitis, the higher the risk of pancreatic cancer. The risk of pancreatic cancer increases significantly in the first 3 years of the course of pancreatitis. This may provide an alternative strategy for the early identification of individuals at high risk of pancreatic cancer.https://doi.org/10.1177/15330338231164875 |
| spellingShingle | Dong-Mei Ma MD Xiao-Wu Dong PhD Xiao Han MS Zhi Ling MS Guo-Tao Lu PhD Yun-Yun Sun PhD Xu-Dong Yin PhD Pancreatitis and Pancreatic Cancer Risk Technology in Cancer Research & Treatment |
| title | Pancreatitis and Pancreatic Cancer Risk |
| title_full | Pancreatitis and Pancreatic Cancer Risk |
| title_fullStr | Pancreatitis and Pancreatic Cancer Risk |
| title_full_unstemmed | Pancreatitis and Pancreatic Cancer Risk |
| title_short | Pancreatitis and Pancreatic Cancer Risk |
| title_sort | pancreatitis and pancreatic cancer risk |
| url | https://doi.org/10.1177/15330338231164875 |
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