NSAID targets SIRT3 to trigger mitochondrial dysfunction and gastric cancer cell death

NSAID targets SIRT3 to trigger mitochondrial dysfunction and gastric cancer cell death

Summary: Gastric cancer (GC) is a deadly malignancy that demands effective therapeutic intervention capitalizing unique drug target/s. Here, we report that indomethacin, a cyclooxygenase non-selective non-steroidal anti-inflammatory drug, arrests GC cell growth by targeting mitochondrial deacetylase...

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Bibliographic Details
Main Authors: Subhashis Debsharma, Saikat Pramanik, Samik Bindu, Somnath Mazumder, Troyee Das, Uttam Pal, Debanjan Saha, Rudranil De, Shiladitya Nag, Chinmoy Banerjee, Nakul Chandra Maiti, Zhumur Ghosh, Uday Bandyopadhyay
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224006059

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