Characterization of Electrospun Poly(ε-caprolactone) Nano/Micro Fibrous Membrane as Scaffolds in Tissue Engineering: Effects of the Type of Collector Used
Electrospinning is an electrohydrodynamic technique that transforms a polymer solution into nano/microscopic diameter fibers under the influence of a high-voltage electric field. Its use in the fabrication of nano/micro fibrous membranes as scaffolds for tissue engineering has increased rapidly in r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Membranes |
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| Online Access: | https://www.mdpi.com/2077-0375/12/6/563 |
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| author | Dianney Clavijo-Grimaldo Ciro Alfonso Casadiego-Torrado Juan Villalobos-Elías Adolfo Ocampo-Páramo Magreth Torres-Parada |
| author_facet | Dianney Clavijo-Grimaldo Ciro Alfonso Casadiego-Torrado Juan Villalobos-Elías Adolfo Ocampo-Páramo Magreth Torres-Parada |
| author_sort | Dianney Clavijo-Grimaldo |
| collection | DOAJ |
| description | Electrospinning is an electrohydrodynamic technique that transforms a polymer solution into nano/microscopic diameter fibers under the influence of a high-voltage electric field. Its use in the fabrication of nano/micro fibrous membranes as scaffolds for tissue engineering has increased rapidly in recent years due to its efficiency and reproducibility. The objective of this study is to show how the use of the same polymeric solution (polycaprolactone 9% <i>w</i>/<i>v</i> in chloroform: isopropanol 50:50) and identical electrohydrodynamic deposition parameters produces fibers with different characteristics using a flat collector platform with movements in the X and Y axes vs. a conventional rotary collector. The manufactured nano/microfibers show significant differences in most of their characteristics (morphology, roughness, hydrophilicity, and mechanical properties). Regarding the diameter and porosity of the fibers, the results were similar. Given that scaffolds must be designed to guarantee adequate survival and the proliferation and migration of a certain cell type, in this study we analyze how the variations in the characteristics of the fibers obtained are essential to defining their potential application. |
| first_indexed | 2024-03-09T23:06:25Z |
| format | Article |
| id | doaj.art-f475802f6d3f4d35a649bd3973b35cbb |
| institution | Directory Open Access Journal |
| issn | 2077-0375 |
| language | English |
| last_indexed | 2024-03-09T23:06:25Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Membranes |
| spelling | doaj.art-f475802f6d3f4d35a649bd3973b35cbb2023-11-23T17:53:56ZengMDPI AGMembranes2077-03752022-05-0112656310.3390/membranes12060563Characterization of Electrospun Poly(ε-caprolactone) Nano/Micro Fibrous Membrane as Scaffolds in Tissue Engineering: Effects of the Type of Collector UsedDianney Clavijo-Grimaldo0Ciro Alfonso Casadiego-Torrado1Juan Villalobos-Elías2Adolfo Ocampo-Páramo3Magreth Torres-Parada4School of Medicine, Universidad Nacional de Colombia, Bogotá 111321, ColombiaSchool of Medicine, Fundación Universitaria Sanitas, Bogotá 111321, ColombiaSchool of Medicine, Universidad Nacional de Colombia, Bogotá 111321, ColombiaSchool of Medicine, Universidad Nacional de Colombia, Bogotá 111321, ColombiaSchool of Medicine, Universidad Nacional de Colombia, Bogotá 111321, ColombiaElectrospinning is an electrohydrodynamic technique that transforms a polymer solution into nano/microscopic diameter fibers under the influence of a high-voltage electric field. Its use in the fabrication of nano/micro fibrous membranes as scaffolds for tissue engineering has increased rapidly in recent years due to its efficiency and reproducibility. The objective of this study is to show how the use of the same polymeric solution (polycaprolactone 9% <i>w</i>/<i>v</i> in chloroform: isopropanol 50:50) and identical electrohydrodynamic deposition parameters produces fibers with different characteristics using a flat collector platform with movements in the X and Y axes vs. a conventional rotary collector. The manufactured nano/microfibers show significant differences in most of their characteristics (morphology, roughness, hydrophilicity, and mechanical properties). Regarding the diameter and porosity of the fibers, the results were similar. Given that scaffolds must be designed to guarantee adequate survival and the proliferation and migration of a certain cell type, in this study we analyze how the variations in the characteristics of the fibers obtained are essential to defining their potential application.https://www.mdpi.com/2077-0375/12/6/563electrospinningpolycaprolactonescaffoldtissue engineering |
| spellingShingle | Dianney Clavijo-Grimaldo Ciro Alfonso Casadiego-Torrado Juan Villalobos-Elías Adolfo Ocampo-Páramo Magreth Torres-Parada Characterization of Electrospun Poly(ε-caprolactone) Nano/Micro Fibrous Membrane as Scaffolds in Tissue Engineering: Effects of the Type of Collector Used Membranes electrospinning polycaprolactone scaffold tissue engineering |
| title | Characterization of Electrospun Poly(ε-caprolactone) Nano/Micro Fibrous Membrane as Scaffolds in Tissue Engineering: Effects of the Type of Collector Used |
| title_full | Characterization of Electrospun Poly(ε-caprolactone) Nano/Micro Fibrous Membrane as Scaffolds in Tissue Engineering: Effects of the Type of Collector Used |
| title_fullStr | Characterization of Electrospun Poly(ε-caprolactone) Nano/Micro Fibrous Membrane as Scaffolds in Tissue Engineering: Effects of the Type of Collector Used |
| title_full_unstemmed | Characterization of Electrospun Poly(ε-caprolactone) Nano/Micro Fibrous Membrane as Scaffolds in Tissue Engineering: Effects of the Type of Collector Used |
| title_short | Characterization of Electrospun Poly(ε-caprolactone) Nano/Micro Fibrous Membrane as Scaffolds in Tissue Engineering: Effects of the Type of Collector Used |
| title_sort | characterization of electrospun poly ε caprolactone nano micro fibrous membrane as scaffolds in tissue engineering effects of the type of collector used |
| topic | electrospinning polycaprolactone scaffold tissue engineering |
| url | https://www.mdpi.com/2077-0375/12/6/563 |
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