Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation

Macrophage STING signaling promotes NK cell to suppress colorectal cancer liver metastasis via 4-1BBL/4-1BB co-stimulation

Background and aims Macrophage innate immune response plays an important role in tumorigenesis. However, the role and mechanism of macrophage STING signaling in modulating tumor microenvironment to suppress tumor growth at secondary sites remains largely unclear.Methods STING expression was assessed...

Full description

Bibliographic Details
Main Authors:	Zheng Liu, Jian Xu, Yu Sun, Ping Wang, Zhuqing Rao, Haoran Hu, Yiyun Gao, Xinyu Zhan, Shun Zhou, Weizhe Zhong, Dongming Wu, Lianbao Kong, Haoming Zhou
Format:	Article
Language:	English
Published:	BMJ Publishing Group 2023-03-01
Series:	Journal for ImmunoTherapy of Cancer
Online Access:	https://jitc.bmj.com/content/11/3/e006481.full

Similar Items

The TNF receptor-ligands 4-1BB-4-1BBL and GITR-GITRL in NK cell responses
by: Isabel eBarao
Published: (2013-01-01)

Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus.
by: DeBenedette, M, et al.
Published: (1999)

Involvement of the 4-1BB/4-1BBL pathway in control of monocyte numbers by invariant NKT cells.
by: Cole, S, et al.
Published: (2014)

The involvement of 4‐1BB/4‐1BBL signaling in glial cell‐mediated hypothalamic inflammation in obesity
by: Jiye Kim, et al.
Published: (2018-05-01)

Galectin-3 Decreases 4-1BBL Bioactivity by Crosslinking Soluble and Membrane Expressed 4-1BB
by: Morten Aagaard Nielsen, et al.
Published: (2022-06-01)

Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.
by: Bérengère Vire, et al.
Published: (2009-09-01)

Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury
by: Haoran Hu, et al.
Published: (2023-07-01)

MLKL deficiency attenuated hepatocyte oxidative DNA damage by activating mitophagy to suppress macrophage cGAS-STING signaling during liver ischemia and reperfusion injury
by: Jian Xu, et al.
Published: (2023-02-01)

S234: CLINICAL-GRADE MBIL21/4-1BBL EXPANDED NK CELLS EXHIBIT STRONGER COMPETENCE COMPARED WITH PRIMARY NK CELLS AGAINST HCMV INFECTION
by: Q.-N. Shang, et al.
Published: (2022-06-01)

Redirecting T cells to glypican-3 with 28.41BB.ζ and 28.ζ-41BBL CARs for hepatocellular carcinoma treatment
by: Haili Ma, et al.
Published: (2017-11-01)

TIGIT contributes to the regulation of 4-1BB and does not define NK cell dysfunction in glioblastoma
by: Kyle B. Lupo, et al.
Published: (2023-12-01)

Prime-boost vaccination with SA-4-1BBL costimulatory molecule and survivin eradicates lung carcinoma in CD8+ T and NK cell dependent manner.
by: Abhishek K Srivastava, et al.
Published: (2012-01-01)

Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab
by: Yan Li, et al.
Published: (2018-10-01)

4-1BB immunotherapy: advances and hurdles
by: Rohit Singh, et al.
Published: (2024-01-01)

STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells
by: Lu Lu, et al.
Published: (2023-09-01)

Route of 41BB/41BBL Costimulation Determines Effector Function of B7-H3-CAR.CD28ζ T Cells
by: Phuong Nguyen, et al.
Published: (2020-09-01)

Natural killer cells drive 4-1BBL positive uveal melanoma towards EMT and metastatic disease
by: Shi Yong Neo, et al.
Published: (2024-01-01)

4-1BBL as a Mediator of Cross-Talk between Innate, Adaptive, and Regulatory Immunity against Cancer
by: Alejandra G. Martinez-Perez, et al.
Published: (2021-06-01)

Correlation of 4-1BBL+ B Cells in Tumor Draining Lymph Nodes with Pathological Characteristics of Breast Cancer
by: Mohsen Arabpour, et al.
Published: (2019-06-01)

MicroRNA-22 Regulates the Pro-inflammatory Responses and M1 Polarization of Macrophages by Targeting GLUT1 and 4-1BBL
by: Young Jun Kang
Published: (2023-01-01)

4‐1BB and cytokines trigger human NK, γδ T, and CD8+ T cell proliferation and activation, but are not required for their effector functions
by: Laurent Vidard
Published: (2023-01-01)

Exploring Synergy in Combinations of Tumor-Derived Vaccines That Harbor 4-1BBL, OX40L, and GM-CSF
by: Andrea J. Manrique-Rincón, et al.
Published: (2017-09-01)

HIV-1 adenoviral vector vaccines expressing multi-trimeric BAFF and 4-1BBL enhance T cell mediated anti-viral immunity.
by: Saravana Kanagavelu, et al.
Published: (2014-01-01)

SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
by: Shravan Madireddi, et al.
Published: (2012-01-01)

745 Oncolytic adenovirus expressing 4-1BBL demonstrates a significant increase of survival in Diffuse Midline Glioma models
by: Sara Labiano, et al.
Published: (2021-11-01)

4-1BB: A promising target for cancer immunotherapy
by: Alyssa Min Jung Kim, et al.
Published: (2022-09-01)

Accelerating Cancer Immunotherapy Through 4-1BB Activation
by: Todd eBartkowiak, et al.
Published: (2015-06-01)

Correction: SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4+ T Cells into CD4+FoxP3+ T Regulatory Cells by Production of IFN-γ
Published: (2012-01-01)

Correction: SA-4-1BBL Costimulation Inhibits Conversion of Conventional CD4 T Cells into CD4FoxP3 T Regulatory Cells by Production of IFN-γ.
by: Shravan Madireddi, et al.
Published: (2012-01-01)

Efficacy of bivalent CEACAM6/4-1BBL genetic vaccine combined with anti-PD1 antibody in MC38 tumor model of mice
by: Yuzhen Li, et al.
Published: (2022-10-01)

Editorial: Cutting-edge liver surgery-based modalities for diagnosis and treatment of liver tumors
by: Haoran Hu, et al.
Published: (2023-08-01)

4-1BBL enhances CD8+ T cell responses induced by vectored vaccines in mice but fails to improve immunogenicity in rhesus macaques.
by: Spencer, A, et al.
Published: (2014)

1192 A novel MSLN×4–1BB bispecific antibody for solid tumor
by: Guodong Shen, et al.
Published: (2023-11-01)

Effects of the Temperature and Salt Concentration on the Structural Characteristics of the Protein (PDB Code 1BBL)
by: Dongqing Shao, et al.
Published: (2022-05-01)

892 ABL503 (TJ-L14B), PD-L1x4–1BB bispecific antibody induces superior anti-tumor activity by PD-L1-dependent 4–1BB activation with the increase of 4–1BB+CD8+ T cells in tumor microenvironment
by: Wenqing Jiang, et al.
Published: (2021-11-01)

Targeting 4-1BB for tumor immunotherapy from bench to bedside
by: Ya-Tao Wang, et al.
Published: (2022-09-01)

Immunotherapy with 4-1BBL-Expressing iPS Cell‐Derived Myeloid Lines Amplifies Antigen-Specific T Cell Infiltration in Advanced Melanoma
by: Haruka Kuriyama, et al.
Published: (2021-02-01)

328 Batf3 dendritic cells and 4–1BB/4–1BB ligand axis are required at the effector phase within the tumor microenvironment for anti-PD-L1 efficacy
by: Thomas Gajewski, et al.
Published: (2021-11-01)

In silico and phylogenetic analyses of partial BbRAP-1, BbCP2, BbSBP-4 and BbβTUB gene sequences of Babesia bovis isolates from cattle in South Africa
by: Phillip Senzo Mtshali, et al.
Published: (2017-12-01)

Agonism of 4-1BB for immune therapy: a perspective on possibilities and complications
by: Shahram Salek-Ardakani, et al.
Published: (2023-08-01)