Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses
In light of the COVID-19 global pandemic caused by SARS-CoV-2, ongoing research has centered on minimizing viral spread either by stopping viral entry or inhibiting viral replication. Repurposing antiviral drugs, typically nucleoside analogs, has proven successful at inhibiting virus replication. Th...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-09-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/13/10/1452 |
| _version_ | 1827721555790004224 |
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| author | Ahmed M. Awad Kamryn Hansen Diana Del Rio Derek Flores Reham F. Barghash Laura Kakkola Ilkka Julkunen Kareem Awad |
| author_facet | Ahmed M. Awad Kamryn Hansen Diana Del Rio Derek Flores Reham F. Barghash Laura Kakkola Ilkka Julkunen Kareem Awad |
| author_sort | Ahmed M. Awad |
| collection | DOAJ |
| description | In light of the COVID-19 global pandemic caused by SARS-CoV-2, ongoing research has centered on minimizing viral spread either by stopping viral entry or inhibiting viral replication. Repurposing antiviral drugs, typically nucleoside analogs, has proven successful at inhibiting virus replication. This review summarizes current information regarding coronavirus classification and characterization and presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge on the chemical nature of proposed therapeutics and their target biomolecules to assist in the identification of potentially new drugs for the treatment of SARS-CoV-2 infection. |
| first_indexed | 2024-03-10T21:25:01Z |
| format | Article |
| id | doaj.art-f47641ef4b5a4dd88835e08f1f46bb4b |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T21:25:01Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-f47641ef4b5a4dd88835e08f1f46bb4b2023-11-19T15:49:27ZengMDPI AGBiomolecules2218-273X2023-09-011310145210.3390/biom13101452Insights into COVID-19: Perspectives on Drug Remedies and Host Cell ResponsesAhmed M. Awad0Kamryn Hansen1Diana Del Rio2Derek Flores3Reham F. Barghash4Laura Kakkola5Ilkka Julkunen6Kareem Awad7Department of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USADepartment of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USADepartment of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USADepartment of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USAInstitute of Chemical Industries Research, National Research Centre, Dokki, Cairo 12622, EgyptInstitute of Biomedicine, Faculty of Medicine, University of Turku, 20014 Turku, FinlandInstitute of Biomedicine, Faculty of Medicine, University of Turku, 20014 Turku, FinlandInstitute of Biomedicine, Faculty of Medicine, University of Turku, 20014 Turku, FinlandIn light of the COVID-19 global pandemic caused by SARS-CoV-2, ongoing research has centered on minimizing viral spread either by stopping viral entry or inhibiting viral replication. Repurposing antiviral drugs, typically nucleoside analogs, has proven successful at inhibiting virus replication. This review summarizes current information regarding coronavirus classification and characterization and presents the broad clinical consequences of SARS-CoV-2 activation of the angiotensin-converting enzyme 2 (ACE2) receptor expressed in different human cell types. It provides publicly available knowledge on the chemical nature of proposed therapeutics and their target biomolecules to assist in the identification of potentially new drugs for the treatment of SARS-CoV-2 infection.https://www.mdpi.com/2218-273X/13/10/1452coronavirusCOVID-19target cell responsesdrug designnucleoside analogsACE2 |
| spellingShingle | Ahmed M. Awad Kamryn Hansen Diana Del Rio Derek Flores Reham F. Barghash Laura Kakkola Ilkka Julkunen Kareem Awad Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses Biomolecules coronavirus COVID-19 target cell responses drug design nucleoside analogs ACE2 |
| title | Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses |
| title_full | Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses |
| title_fullStr | Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses |
| title_full_unstemmed | Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses |
| title_short | Insights into COVID-19: Perspectives on Drug Remedies and Host Cell Responses |
| title_sort | insights into covid 19 perspectives on drug remedies and host cell responses |
| topic | coronavirus COVID-19 target cell responses drug design nucleoside analogs ACE2 |
| url | https://www.mdpi.com/2218-273X/13/10/1452 |
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