PD-L1 Mediates IFNγ-Regulation of Glucose but Not of Tryptophan Metabolism in Clear Cell Renal Cell Carcinoma

PD-L1 Mediates IFNγ-Regulation of Glucose but Not of Tryptophan Metabolism in Clear Cell Renal Cell Carcinoma

The immune checkpoint programmed death-ligand 1 (PD-L1) is expressed on the cell surface of tumor cells and is key for maintaining an immunosuppressive microenvironment through its interaction with the programmed death 1 (PD-1). Clear cell renal cell carcinoma (ccRCC) is a highly immunogenic cancer...

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Bibliographic Details
Main Authors: Mamatha Garige, Susmita Ghosh, Alexis Norris, Guangyuan Li, Sarah Poncet, Chao-Kai Chou, Wells W. Wu, Rong-Fong Shen, Carole Sourbier
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
PD-L1 (B7-H1
CD274)
clear cell renal cell carcinoma (ccRCC)
interferon gamma
metabolism
tryptophan
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.858379/full

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