Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views
Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/12/3638 |
| _version_ | 1797545786674774016 |
|---|---|
| author | Moon Jong Kim Yuanjian Huang Jae-Il Park |
| author_facet | Moon Jong Kim Yuanjian Huang Jae-Il Park |
| author_sort | Moon Jong Kim |
| collection | DOAJ |
| description | Wnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment. |
| first_indexed | 2024-03-10T14:19:57Z |
| format | Article |
| id | doaj.art-f47a9d74e25e4f0aa21cd5339275681a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T14:19:57Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f47a9d74e25e4f0aa21cd5339275681a2023-11-20T23:29:55ZengMDPI AGCancers2072-66942020-12-011212363810.3390/cancers12123638Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving ViewsMoon Jong Kim0Yuanjian Huang1Jae-Il Park2Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USAWnt signaling governs tissue development, homeostasis, and regeneration. However, aberrant activation of Wnt promotes tumorigenesis. Despite the ongoing efforts to manipulate Wnt signaling, therapeutic targeting of Wnt signaling remains challenging. In this review, we provide an overview of current clinical trials to target Wnt signaling, with a major focus on gastrointestinal cancers. In addition, we discuss the caveats and alternative strategies for therapeutically targeting Wnt signaling for cancer treatment.https://www.mdpi.com/2072-6694/12/12/3638Wnt signalingβ-catenincancergastrointestinal cancerstherapeutic targeting of Wnt signalingβ-catenin paradox |
| spellingShingle | Moon Jong Kim Yuanjian Huang Jae-Il Park Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views Cancers Wnt signaling β-catenin cancer gastrointestinal cancers therapeutic targeting of Wnt signaling β-catenin paradox |
| title | Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views |
| title_full | Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views |
| title_fullStr | Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views |
| title_full_unstemmed | Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views |
| title_short | Targeting Wnt Signaling for Gastrointestinal Cancer Therapy: Present and Evolving Views |
| title_sort | targeting wnt signaling for gastrointestinal cancer therapy present and evolving views |
| topic | Wnt signaling β-catenin cancer gastrointestinal cancers therapeutic targeting of Wnt signaling β-catenin paradox |
| url | https://www.mdpi.com/2072-6694/12/12/3638 |
| work_keys_str_mv | AT moonjongkim targetingwntsignalingforgastrointestinalcancertherapypresentandevolvingviews AT yuanjianhuang targetingwntsignalingforgastrointestinalcancertherapypresentandevolvingviews AT jaeilpark targetingwntsignalingforgastrointestinalcancertherapypresentandevolvingviews |