Angiogenesis-related proteins as biomarkers for peripheral artery disease
Background: Angiogenesis plays an important role in peripheral artery disease (PAD) and angiogenesis-related proteins may act as prognostic biomarkers. This study assesses the potential for angiogenesis-related proteins to predict adverse events associated with PAD. Methods: This was a case-control...
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| Format: | Article |
| Jezik: | English |
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Elsevier
2023-09-01
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| Serija: | Heliyon |
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| Online dostop: | http://www.sciencedirect.com/science/article/pii/S2405844023073747 |
| _version_ | 1827803057510940672 |
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| author | Ben Li Niousha Djahanpour Abdelrahman Zamzam Muzammil H. Syed Shubha Jain Rawand Abdin Mohammad Qadura |
| author_facet | Ben Li Niousha Djahanpour Abdelrahman Zamzam Muzammil H. Syed Shubha Jain Rawand Abdin Mohammad Qadura |
| author_sort | Ben Li |
| collection | DOAJ |
| description | Background: Angiogenesis plays an important role in peripheral artery disease (PAD) and angiogenesis-related proteins may act as prognostic biomarkers. This study assesses the potential for angiogenesis-related proteins to predict adverse events associated with PAD. Methods: This was a case-control study. Patients with PAD (n = 250) and without PAD (n = 125) provided blood samples and were followed prospectively for three years. Concentrations of 17 angiogenesis-related proteins were measured in plasma. The incidence of major adverse limb event (MALE), defined as a composite of major amputation or vascular intervention, was the primary outcome. Worsening PAD status, defined as a drop in ankle brachial index ≥ 0.15, was the secondary outcome. Multivariable regression adjusted for baseline characteristics was conducted to determine the prognostication value of angiogenesis-related proteins in predicting MALE. Findings: Relative to patients without PAD, 8 proteins related to angiogenesis were expressed differentially in PAD patients. Worsening PAD status and MALE were observed in 52 (14%) and 83 (22%) patients, respectively. Hepatocyte growth factor (HGF) was the most reliable predictor of MALE (adjusted HR 0.79, 95% CI 0.15–0.86). Compared to individuals with high HGF, patients with low HGF had a decreased three-year freedom from MALE [66% vs 88%, p = 0.001], major amputation [93% vs 98%, p = 0.023], vascular intervention [68% vs 88%, p = 0.001], and worsening PAD status [81% vs 91%, p = 0.006]. Interpretation: Measuring plasma levels of HGF in individuals with PAD can assist in identifying patients at elevated risk of adverse events related to PAD who may benefit from additional evaluation or treatment. |
| first_indexed | 2024-03-11T20:48:57Z |
| format | Article |
| id | doaj.art-f47b3cefb88a45af9c0a1bd502f367cd |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T20:48:57Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f47b3cefb88a45af9c0a1bd502f367cd2023-10-01T06:02:45ZengElsevierHeliyon2405-84402023-09-0199e20166Angiogenesis-related proteins as biomarkers for peripheral artery diseaseBen Li0Niousha Djahanpour1Abdelrahman Zamzam2Muzammil H. Syed3Shubha Jain4Rawand Abdin5Mohammad Qadura6Division of Vascular Surgery, St. Michael's Hospital, Unity Health Toronto, University of Toronto, CanadaDivision of Vascular Surgery, St. Michael's Hospital, Unity Health Toronto, University of Toronto, CanadaDivision of Vascular Surgery, St. Michael's Hospital, Unity Health Toronto, University of Toronto, CanadaDivision of Vascular Surgery, St. Michael's Hospital, Unity Health Toronto, University of Toronto, CanadaDivision of Vascular Surgery, St. Michael's Hospital, Unity Health Toronto, University of Toronto, CanadaDepartment of Medicine, McMaster University, Hamilton, CanadaDivision of Vascular Surgery, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Canada; Department of Surgery, University of Toronto, Toronto, Canada; Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Canada; Corresponding author. University of Toronto, Division of Vascular Surgery, St. Michael's Hospital, Unity Health Toronto, 30 Bond Street, Suite 7-076, Toronto, Ontario, M5B 1W8, Canada.Background: Angiogenesis plays an important role in peripheral artery disease (PAD) and angiogenesis-related proteins may act as prognostic biomarkers. This study assesses the potential for angiogenesis-related proteins to predict adverse events associated with PAD. Methods: This was a case-control study. Patients with PAD (n = 250) and without PAD (n = 125) provided blood samples and were followed prospectively for three years. Concentrations of 17 angiogenesis-related proteins were measured in plasma. The incidence of major adverse limb event (MALE), defined as a composite of major amputation or vascular intervention, was the primary outcome. Worsening PAD status, defined as a drop in ankle brachial index ≥ 0.15, was the secondary outcome. Multivariable regression adjusted for baseline characteristics was conducted to determine the prognostication value of angiogenesis-related proteins in predicting MALE. Findings: Relative to patients without PAD, 8 proteins related to angiogenesis were expressed differentially in PAD patients. Worsening PAD status and MALE were observed in 52 (14%) and 83 (22%) patients, respectively. Hepatocyte growth factor (HGF) was the most reliable predictor of MALE (adjusted HR 0.79, 95% CI 0.15–0.86). Compared to individuals with high HGF, patients with low HGF had a decreased three-year freedom from MALE [66% vs 88%, p = 0.001], major amputation [93% vs 98%, p = 0.023], vascular intervention [68% vs 88%, p = 0.001], and worsening PAD status [81% vs 91%, p = 0.006]. Interpretation: Measuring plasma levels of HGF in individuals with PAD can assist in identifying patients at elevated risk of adverse events related to PAD who may benefit from additional evaluation or treatment.http://www.sciencedirect.com/science/article/pii/S2405844023073747Angiogenesis-related proteinsHepatocyte growth factor (HGF)BiomarkersPeripheral artery disease |
| spellingShingle | Ben Li Niousha Djahanpour Abdelrahman Zamzam Muzammil H. Syed Shubha Jain Rawand Abdin Mohammad Qadura Angiogenesis-related proteins as biomarkers for peripheral artery disease Heliyon Angiogenesis-related proteins Hepatocyte growth factor (HGF) Biomarkers Peripheral artery disease |
| title | Angiogenesis-related proteins as biomarkers for peripheral artery disease |
| title_full | Angiogenesis-related proteins as biomarkers for peripheral artery disease |
| title_fullStr | Angiogenesis-related proteins as biomarkers for peripheral artery disease |
| title_full_unstemmed | Angiogenesis-related proteins as biomarkers for peripheral artery disease |
| title_short | Angiogenesis-related proteins as biomarkers for peripheral artery disease |
| title_sort | angiogenesis related proteins as biomarkers for peripheral artery disease |
| topic | Angiogenesis-related proteins Hepatocyte growth factor (HGF) Biomarkers Peripheral artery disease |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023073747 |
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