ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA
The effect of Justicia gendarussa leaves extract has been investigated using oxonate-induced hyperuricemic malealbino rats. In this experiment thirty five male albino rats were divided randomly into seven groups. There were threegroup doses variations of J. gendarussa extract that were 1.3 g/kg bw,...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Universitas Indonesia
2011-04-01
|
| Series: | Makara Seri Sains |
| Subjects: | |
| Online Access: | http://journal.ui.ac.id/science/article/view/881/840 |
| _version_ | 1828435576576016384 |
|---|---|
| author | Muhamad Iqbal Julian Department of Pharmacy, Faculty Mathematics and Sciences, University of Indonesia, Depok 16424, Indonesia Berna Elya Katrin Basah |
| author_facet | Muhamad Iqbal Julian Department of Pharmacy, Faculty Mathematics and Sciences, University of Indonesia, Depok 16424, Indonesia Berna Elya Katrin Basah |
| author_sort | Muhamad Iqbal Julian |
| collection | DOAJ |
| description | The effect of Justicia gendarussa leaves extract has been investigated using oxonate-induced hyperuricemic malealbino rats. In this experiment thirty five male albino rats were divided randomly into seven groups. There were threegroup doses variations of J. gendarussa extract that were 1.3 g/kg bw, 2.6 g/kg bw and 5.2 g/kg bw; two comparisongroups that were allopurinol 0.68 g/kg bw and herbal “X” 0.85 g/kg bw; and two control groups that were inducedcontrol potassium oxonate 0.25 mg/kg bw and normal control CMC 0,5 %. Intraperitoneal administration of potassiumoxonate 0.25 mg/kg bw was given one hour before administration of test drugs in eight day and plasma uric acid wasmeasured in rats after two hours. Plasma uric acid was measured by spectrophotometric on 520 nm with enzymaticmethod. The results showed that all extracts could reduced uric acid level of rats. The decreasing potency of uric acidlevel was equal to doses increase, so the best result that can reduce uric acid level was J. gandarussa extract at a dose5.2 g/ kg bw. This results indicated that J. gendarussa leaves extract may be effective for the prevention and thetreatment of hyperuricemia. |
| first_indexed | 2024-12-10T19:09:38Z |
| format | Article |
| id | doaj.art-f47c5f5db31247aea6d088a8c9238cd0 |
| institution | Directory Open Access Journal |
| issn | 1693-6671 |
| language | English |
| last_indexed | 2024-12-10T19:09:38Z |
| publishDate | 2011-04-01 |
| publisher | Universitas Indonesia |
| record_format | Article |
| series | Makara Seri Sains |
| spelling | doaj.art-f47c5f5db31247aea6d088a8c9238cd02022-12-22T01:36:47ZengUniversitas IndonesiaMakara Seri Sains1693-66712011-04-011516770ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMAMuhamad Iqbal JulianDepartment of Pharmacy, Faculty Mathematics and Sciences, University of Indonesia, Depok 16424, IndonesiaBerna ElyaKatrin BasahThe effect of Justicia gendarussa leaves extract has been investigated using oxonate-induced hyperuricemic malealbino rats. In this experiment thirty five male albino rats were divided randomly into seven groups. There were threegroup doses variations of J. gendarussa extract that were 1.3 g/kg bw, 2.6 g/kg bw and 5.2 g/kg bw; two comparisongroups that were allopurinol 0.68 g/kg bw and herbal “X” 0.85 g/kg bw; and two control groups that were inducedcontrol potassium oxonate 0.25 mg/kg bw and normal control CMC 0,5 %. Intraperitoneal administration of potassiumoxonate 0.25 mg/kg bw was given one hour before administration of test drugs in eight day and plasma uric acid wasmeasured in rats after two hours. Plasma uric acid was measured by spectrophotometric on 520 nm with enzymaticmethod. The results showed that all extracts could reduced uric acid level of rats. The decreasing potency of uric acidlevel was equal to doses increase, so the best result that can reduce uric acid level was J. gandarussa extract at a dose5.2 g/ kg bw. This results indicated that J. gendarussa leaves extract may be effective for the prevention and thetreatment of hyperuricemia.http://journal.ui.ac.id/science/article/view/881/840enzymaticshyperuricemiaJusticia gendarussa Burmspectrophotometric |
| spellingShingle | Muhamad Iqbal Julian Department of Pharmacy, Faculty Mathematics and Sciences, University of Indonesia, Depok 16424, Indonesia Berna Elya Katrin Basah ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA Makara Seri Sains enzymatics hyperuricemia Justicia gendarussa Burm spectrophotometric |
| title | ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA |
| title_full | ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA |
| title_fullStr | ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA |
| title_full_unstemmed | ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA |
| title_short | ACTIVITY OF ETHANOLIC EXTRACT FROM Justicia gendarussa Burm. LEAVES ON DECREASING THE URIC ACID PLASMA |
| title_sort | activity of ethanolic extract from justicia gendarussa burm leaves on decreasing the uric acid plasma |
| topic | enzymatics hyperuricemia Justicia gendarussa Burm spectrophotometric |
| url | http://journal.ui.ac.id/science/article/view/881/840 |
| work_keys_str_mv | AT muhamadiqbaljulian activityofethanolicextractfromjusticiagendarussaburmleavesondecreasingtheuricacidplasma AT departmentofpharmacyfacultymathematicsandsciencesuniversityofindonesiadepok16424indonesia activityofethanolicextractfromjusticiagendarussaburmleavesondecreasingtheuricacidplasma AT bernaelya activityofethanolicextractfromjusticiagendarussaburmleavesondecreasingtheuricacidplasma AT katrinbasah activityofethanolicextractfromjusticiagendarussaburmleavesondecreasingtheuricacidplasma |