Neuroantigen-Specific CD4 Cells Expressing Interferon-γ (IFN-γ), Interleukin (IL)-2 and IL-3 in a Mutually Exclusive Manner Prevail in Experimental Allergic Encephalomyelitis (EAE)

Neuroantigen-Specific CD4 Cells Expressing Interferon-γ (IFN-γ), Interleukin (IL)-2 and IL-3 in a Mutually Exclusive Manner Prevail in Experimental Allergic Encephalomyelitis (EAE)

Experimental allergic encephalomyelitis (EAE) is mediated by neuroantigen-specific pro-inflammatory T cells of the Th1 and Th17 effector class. Th-17 cells can be clearly defined by expression of IL-17, but not IFN-γ, IL-2 or IL-3. Th1 cells do not express IL-17, but it is unclear presently to what...

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Bibliographic Details
Main Authors: Paul V. Lehmann, Maike D. Hesse, Stefan Quast, Alexey Y. Karulin
Format: Article
Language:English
Published: MDPI AG 2012-08-01
Series:Cells
Subjects:
EAE/MS
Neuroimmunology
Two-color ELISPOT
Dual color ELISPOT Memory T cells
Th1 cells
cytokine co-expression
polyfunctional T cells
Online Access:http://www.mdpi.com/2073-4409/1/3/576

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