Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia

Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia

Exposure of cancer cells to particular chemotherapeutic agents or γ-irradiation induces a form of cell death that stimulates an immune response in mice. This “immunogenic cell death” requires calreticulin (CRT) translocation to the plasma membrane, which has been shown to promote cancer cell phagocy...

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Bibliographic Details
Main Authors:	Xiufen Chen, Dominick Fosco, Douglas E. Kline, Justin Kline
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2017-04-01
Series:	OncoImmunology
Subjects:	acute myeloid leukemia calreticulin immunity type i interferon
Online Access:	http://dx.doi.org/10.1080/2162402X.2016.1278332

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