Effectiveness in Block by Dexmedetomidine of Hyperpolarization-Activated Cation Current, Independent of Its Agonistic Effect on α<sub>2</sub>-Adrenergic Receptors

Effectiveness in Block by Dexmedetomidine of Hyperpolarization-Activated Cation Current, Independent of Its Agonistic Effect on α<sub>2</sub>-Adrenergic Receptors

Dexmedetomidine (DEX), a highly selective agonist of α<sub>2</sub>-adrenergic receptors, has been tailored for sedation without risk of respiratory depression. Our hypothesis is that DEX produces any direct perturbations on ionic currents (e.g., hyperpolarization-activated cation current...

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Bibliographic Details
Main Authors: Te-Ling Lu, Te-Jung Lu, Sheng-Nan Wu
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
dexmedetomidine
endocrine cells
hyperpolarization-activated cation current
voltage hysteresis
action potential
Online Access:https://www.mdpi.com/1422-0067/21/23/9110

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