Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.

Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway.

The α1A-AR is thought to couple predominantly to the Gαq/PLC pathway and lead to phosphoinositide hydrolysis and calcium mobilization, although certain agonists acting at this receptor have been reported to trigger activation of arachidonic acid formation and MAPK pathways. For several G protein-cou...

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Bibliographic Details
Main Authors: Alicja J Copik, Aleksander Baldys, Khanh Nguyen, Sunil Sahdeo, Hoangdung Ho, Alan Kosaka, Paul J Dietrich, Bill Fitch, John R Raymond, Anthony P D W Ford, Donald Button, Marcos E Milla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4301629?pdf=render

Internet

http://europepmc.org/articles/PMC4301629?pdf=render

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