A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment
Neuroblastoma is the most common extra-cranial pediatric solid tumor that accounts for more than 15% of childhood cancer-related deaths. High risk neuroblastomas that recur during or after intense multimodal therapy have a <5% chance at a second sustained remission or cure. The solid tumor microe...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/18/4650 |
| _version_ | 1797520013415940096 |
|---|---|
| author | Jenny Shim Kelly C. Goldsmith |
| author_facet | Jenny Shim Kelly C. Goldsmith |
| author_sort | Jenny Shim |
| collection | DOAJ |
| description | Neuroblastoma is the most common extra-cranial pediatric solid tumor that accounts for more than 15% of childhood cancer-related deaths. High risk neuroblastomas that recur during or after intense multimodal therapy have a <5% chance at a second sustained remission or cure. The solid tumor microenvironment (TME) has been increasingly recognized to play a critical role in cancer progression and resistance to therapy, including in neuroblastoma. The Yes-Associated Protein (YAP) in the Hippo pathway can regulate cancer proliferation, tumor initiation, and therapy response in many cancer types and as such, its role in the TME has gained interest. In this review, we focus on YAP and its role in neuroblastoma and further describe its demonstrated and potential effects on the neuroblastoma TME. We also discuss the therapeutic strategies for inhibiting YAP in neuroblastoma. |
| first_indexed | 2024-03-10T07:50:49Z |
| format | Article |
| id | doaj.art-f480d2192f7d4d08b16e679582859e4f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T07:50:49Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f480d2192f7d4d08b16e679582859e4f2023-11-22T12:18:27ZengMDPI AGCancers2072-66942021-09-011318465010.3390/cancers13184650A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma MicroenvironmentJenny Shim0Kelly C. Goldsmith1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USADepartment of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USANeuroblastoma is the most common extra-cranial pediatric solid tumor that accounts for more than 15% of childhood cancer-related deaths. High risk neuroblastomas that recur during or after intense multimodal therapy have a <5% chance at a second sustained remission or cure. The solid tumor microenvironment (TME) has been increasingly recognized to play a critical role in cancer progression and resistance to therapy, including in neuroblastoma. The Yes-Associated Protein (YAP) in the Hippo pathway can regulate cancer proliferation, tumor initiation, and therapy response in many cancer types and as such, its role in the TME has gained interest. In this review, we focus on YAP and its role in neuroblastoma and further describe its demonstrated and potential effects on the neuroblastoma TME. We also discuss the therapeutic strategies for inhibiting YAP in neuroblastoma.https://www.mdpi.com/2072-6694/13/18/4650neuroblastomatumor microenvironmentyes-associated proteinhippo pathwayhypoxiaangiogenesis |
| spellingShingle | Jenny Shim Kelly C. Goldsmith A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment Cancers neuroblastoma tumor microenvironment yes-associated protein hippo pathway hypoxia angiogenesis |
| title | A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment |
| title_full | A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment |
| title_fullStr | A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment |
| title_full_unstemmed | A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment |
| title_short | A New Player in Neuroblastoma: YAP and Its Role in the Neuroblastoma Microenvironment |
| title_sort | new player in neuroblastoma yap and its role in the neuroblastoma microenvironment |
| topic | neuroblastoma tumor microenvironment yes-associated protein hippo pathway hypoxia angiogenesis |
| url | https://www.mdpi.com/2072-6694/13/18/4650 |
| work_keys_str_mv | AT jennyshim anewplayerinneuroblastomayapanditsroleintheneuroblastomamicroenvironment AT kellycgoldsmith anewplayerinneuroblastomayapanditsroleintheneuroblastomamicroenvironment AT jennyshim newplayerinneuroblastomayapanditsroleintheneuroblastomamicroenvironment AT kellycgoldsmith newplayerinneuroblastomayapanditsroleintheneuroblastomamicroenvironment |