TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors
With recent progress in understanding the pathogenesis of adrenocortical tumors (ACTs), identification of molecular markers to predict their prognosis has become possible. Transcription factor 21 (TCF21)/podocyte-expressed 1 (POD1) is a transcriptional regulatory protein expressed in mesenchymal cel...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fendo.2018.00038/full |
| _version_ | 1819236624324624384 |
|---|---|
| author | Barbara dos Santos Passaia Matheus Henrique Dias Jean Lucas Kremer Sonir Roberto Rauber Antonini Madson Queiroz de Almeida Maria Candida Barisson Villares Fragoso Claudimara Ferini Pacicco Lotfi |
| author_facet | Barbara dos Santos Passaia Matheus Henrique Dias Jean Lucas Kremer Sonir Roberto Rauber Antonini Madson Queiroz de Almeida Maria Candida Barisson Villares Fragoso Claudimara Ferini Pacicco Lotfi |
| author_sort | Barbara dos Santos Passaia |
| collection | DOAJ |
| description | With recent progress in understanding the pathogenesis of adrenocortical tumors (ACTs), identification of molecular markers to predict their prognosis has become possible. Transcription factor 21 (TCF21)/podocyte-expressed 1 (POD1) is a transcriptional regulatory protein expressed in mesenchymal cells at sites of epithelial–mesenchymal transition during the development of different systems. Adult carcinomas express less TCF21 than adenomas, in addition, the KEGG pathway analysis has shown that BUB1B, among others genes, is negatively correlated with TCF21 expression. The difference between BUB1B and PTEN-induced putative kinase 1 (PINK1) expression has been described previously to be associated with survival in adult but not in pediatric carcinomas. Here, we analyzed the gene expression of TCF21, BUB1B, PINK1, and NR5A1 in adult and pediatric ACTs. We found a negative correlation between the relative expression levels of TCF21 and BUB1B in adult ACTs, but the relative expression levels of TCF21, BUB1B, PINK1, and NR5A1 were similar in childhood ACTs. In addition, we propose using the subtracted expression levels of the TCF21/POD-1 genes as a predictor of overall survival (OS) in adult carcinomas and TCF21-NR5A1 as a predictor of malignancy for pediatric tumors in patients aged <5 years. These results require further validation in different cohorts of both adult and pediatric samples. Finally, we observed that the OS for patients aged <5 years was markedly favorable compared with that for patients >5 years as well as adult patients with carcinoma. In summary, we propose TCF21/POD-1 as a new prognostic marker in adult and pediatric ACTs. |
| first_indexed | 2024-12-23T13:07:24Z |
| format | Article |
| id | doaj.art-f48108fbdd974727ab7feb233385d6bf |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-23T13:07:24Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f48108fbdd974727ab7feb233385d6bf2022-12-21T17:45:50ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-02-01910.3389/fendo.2018.00038315333TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical TumorsBarbara dos Santos Passaia0Matheus Henrique Dias1Jean Lucas Kremer2Sonir Roberto Rauber Antonini3Madson Queiroz de Almeida4Maria Candida Barisson Villares Fragoso5Claudimara Ferini Pacicco Lotfi6Department of Anatomy, Institute of Biomedical Science, University of São Paulo, São Paulo, BrazilSpecial Laboratory of Applied Toxicology (LETA), Butantan Institute, São Paulo, BrazilDepartment of Anatomy, Institute of Biomedical Science, University of São Paulo, São Paulo, BrazilDepartment of Pediatrics and Puericulture, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, BrazilAdrenal Unit, Hormone and Molecular Genetic Laboratory/LIM42, Hospital of Clinics, School of Medicine, University of São Paulo, São Paulo, BrazilAdrenal Unit, Hormone and Molecular Genetic Laboratory/LIM42, Hospital of Clinics, School of Medicine, University of São Paulo, São Paulo, BrazilDepartment of Anatomy, Institute of Biomedical Science, University of São Paulo, São Paulo, BrazilWith recent progress in understanding the pathogenesis of adrenocortical tumors (ACTs), identification of molecular markers to predict their prognosis has become possible. Transcription factor 21 (TCF21)/podocyte-expressed 1 (POD1) is a transcriptional regulatory protein expressed in mesenchymal cells at sites of epithelial–mesenchymal transition during the development of different systems. Adult carcinomas express less TCF21 than adenomas, in addition, the KEGG pathway analysis has shown that BUB1B, among others genes, is negatively correlated with TCF21 expression. The difference between BUB1B and PTEN-induced putative kinase 1 (PINK1) expression has been described previously to be associated with survival in adult but not in pediatric carcinomas. Here, we analyzed the gene expression of TCF21, BUB1B, PINK1, and NR5A1 in adult and pediatric ACTs. We found a negative correlation between the relative expression levels of TCF21 and BUB1B in adult ACTs, but the relative expression levels of TCF21, BUB1B, PINK1, and NR5A1 were similar in childhood ACTs. In addition, we propose using the subtracted expression levels of the TCF21/POD-1 genes as a predictor of overall survival (OS) in adult carcinomas and TCF21-NR5A1 as a predictor of malignancy for pediatric tumors in patients aged <5 years. These results require further validation in different cohorts of both adult and pediatric samples. Finally, we observed that the OS for patients aged <5 years was markedly favorable compared with that for patients >5 years as well as adult patients with carcinoma. In summary, we propose TCF21/POD-1 as a new prognostic marker in adult and pediatric ACTs.http://journal.frontiersin.org/article/10.3389/fendo.2018.00038/fulladrenocortical tumorsadult and pediatric tumorstranscription factor 21podocyte-expressed 1BUB1BPTEN-induced putative kinase 1 |
| spellingShingle | Barbara dos Santos Passaia Matheus Henrique Dias Jean Lucas Kremer Sonir Roberto Rauber Antonini Madson Queiroz de Almeida Maria Candida Barisson Villares Fragoso Claudimara Ferini Pacicco Lotfi TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors Frontiers in Endocrinology adrenocortical tumors adult and pediatric tumors transcription factor 21 podocyte-expressed 1 BUB1B PTEN-induced putative kinase 1 |
| title | TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors |
| title_full | TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors |
| title_fullStr | TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors |
| title_full_unstemmed | TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors |
| title_short | TCF21/POD-1, a Transcritional Regulator of SF-1/NR5A1, as a Potential Prognosis Marker in Adult and Pediatric Adrenocortical Tumors |
| title_sort | tcf21 pod 1 a transcritional regulator of sf 1 nr5a1 as a potential prognosis marker in adult and pediatric adrenocortical tumors |
| topic | adrenocortical tumors adult and pediatric tumors transcription factor 21 podocyte-expressed 1 BUB1B PTEN-induced putative kinase 1 |
| url | http://journal.frontiersin.org/article/10.3389/fendo.2018.00038/full |
| work_keys_str_mv | AT barbaradossantospassaia tcf21pod1atranscritionalregulatorofsf1nr5a1asapotentialprognosismarkerinadultandpediatricadrenocorticaltumors AT matheushenriquedias tcf21pod1atranscritionalregulatorofsf1nr5a1asapotentialprognosismarkerinadultandpediatricadrenocorticaltumors AT jeanlucaskremer tcf21pod1atranscritionalregulatorofsf1nr5a1asapotentialprognosismarkerinadultandpediatricadrenocorticaltumors AT sonirrobertorauberantonini tcf21pod1atranscritionalregulatorofsf1nr5a1asapotentialprognosismarkerinadultandpediatricadrenocorticaltumors AT madsonqueirozdealmeida tcf21pod1atranscritionalregulatorofsf1nr5a1asapotentialprognosismarkerinadultandpediatricadrenocorticaltumors AT mariacandidabarissonvillaresfragoso tcf21pod1atranscritionalregulatorofsf1nr5a1asapotentialprognosismarkerinadultandpediatricadrenocorticaltumors AT claudimaraferinipaciccolotfi tcf21pod1atranscritionalregulatorofsf1nr5a1asapotentialprognosismarkerinadultandpediatricadrenocorticaltumors |