Screening of Novel Antimicrobial Diastereomers of Azithromycin–Thiosemicarbazone Conjugates: A Combined LC-SPE/Cryo NMR, MS/MS and Molecular Modeling Approach

Screening of Novel Antimicrobial Diastereomers of Azithromycin–Thiosemicarbazone Conjugates: A Combined LC-SPE/Cryo NMR, MS/MS and Molecular Modeling Approach

A well-known class of antibacterials, 14- and 15-membered macrolides are widely prescribed to treat upper and lower respiratory tract infections. Azithromycin is a 15-membered macrolide antibiotic possessing a broad spectrum of antibacterial potency and favorable pharmacokinetics. Bacterial resistan...

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Bibliographic Details
Main Authors: Iva Habinovec, Ivana Mikulandra, Paula Pranjić, Saša Kazazić, Hana Čipčić Paljetak, Antun Barišić, Branimir Bertoša, Mirjana Bukvić, Predrag Novak
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antibiotics
Subjects:
azithromycin conjugates
macrozones
diastereomers
antibacterial activity
HPLC-SPE/cryo NMR
MS/MS
Online Access:https://www.mdpi.com/2079-6382/11/12/1738

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