Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report
Abstract Background The abscopal effect was described as early as the 1950s, when untreated tumors demonstrated a response after radiation therapy was delivered to an untreated, distant site. The mechanisms underlying this global response to otherwise localized therapy remain unknown, though there i...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13256-020-02512-8 |
| _version_ | 1828970819441655808 |
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| author | Samuel A. Kareff Jonathan W. Lischalk Rebecca Krochmal Chul Kim |
| author_facet | Samuel A. Kareff Jonathan W. Lischalk Rebecca Krochmal Chul Kim |
| author_sort | Samuel A. Kareff |
| collection | DOAJ |
| description | Abstract Background The abscopal effect was described as early as the 1950s, when untreated tumors demonstrated a response after radiation therapy was delivered to an untreated, distant site. The mechanisms underlying this global response to otherwise localized therapy remain unknown, though there is increasing evidence that increased antigen expression following ablative radiotherapy may play a role. Case presentation We report a case of a 69-year-old African American woman with a history of metastatic typical pulmonary carcinoid with multiple lung nodules who had a significant decrease in size of an untreated left upper lobe nodule after stereotactic body radiation therapy to an oligoprogressive left lower lobe lesion. Conclusions To our knowledge, this report describes the first case of an abscopal effect in a typical pulmonary carcinoid. Further research is needed regarding the mechanisms responsible for this finding and the role of combining radiation therapy and cancer immunotherapy in patients with pulmonary carcinoid tumors. |
| first_indexed | 2024-12-14T12:59:30Z |
| format | Article |
| id | doaj.art-f48264b05a2948fca9ee84b26c8340ce |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-12-14T12:59:30Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-f48264b05a2948fca9ee84b26c8340ce2022-12-21T23:00:30ZengBMCJournal of Medical Case Reports1752-19472020-10-011411410.1186/s13256-020-02512-8Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case reportSamuel A. Kareff0Jonathan W. Lischalk1Rebecca Krochmal2Chul Kim3Department of Graduate Medical Education, MedStar Georgetown University HospitalDepartment of Radiation Medicine, MedStar Georgetown University HospitalDepartment of Pulmonology and Critical Care Medicine, MedStar Georgetown University HospitalGeorgetown Lombardi Comprehensive Cancer Center, MedStar Georgetown University HospitalAbstract Background The abscopal effect was described as early as the 1950s, when untreated tumors demonstrated a response after radiation therapy was delivered to an untreated, distant site. The mechanisms underlying this global response to otherwise localized therapy remain unknown, though there is increasing evidence that increased antigen expression following ablative radiotherapy may play a role. Case presentation We report a case of a 69-year-old African American woman with a history of metastatic typical pulmonary carcinoid with multiple lung nodules who had a significant decrease in size of an untreated left upper lobe nodule after stereotactic body radiation therapy to an oligoprogressive left lower lobe lesion. Conclusions To our knowledge, this report describes the first case of an abscopal effect in a typical pulmonary carcinoid. Further research is needed regarding the mechanisms responsible for this finding and the role of combining radiation therapy and cancer immunotherapy in patients with pulmonary carcinoid tumors.http://link.springer.com/article/10.1186/s13256-020-02512-8Abscopal effectNeuroendocrine tumorPulmonary carcinoid |
| spellingShingle | Samuel A. Kareff Jonathan W. Lischalk Rebecca Krochmal Chul Kim Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report Journal of Medical Case Reports Abscopal effect Neuroendocrine tumor Pulmonary carcinoid |
| title | Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report |
| title_full | Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report |
| title_fullStr | Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report |
| title_full_unstemmed | Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report |
| title_short | Abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy: a case report |
| title_sort | abscopal effect in pulmonary carcinoid tumor following ablative stereotactic body radiation therapy a case report |
| topic | Abscopal effect Neuroendocrine tumor Pulmonary carcinoid |
| url | http://link.springer.com/article/10.1186/s13256-020-02512-8 |
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