Design and Microwave Synthesis of New (5<i>Z</i>) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5<i>Z</i>) 2-Amino-5-arylidene-1,3-thiazol-4(5<i>H</i>)-one as New Inhibitors of Protein Kinase DYRK1A

Design and Microwave Synthesis of New (5<i>Z</i>) 5-Arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5<i>Z</i>) 2-Amino-5-arylidene-1,3-thiazol-4(5<i>H</i>)-one as New Inhibitors of Protein Kinase DYRK1A

Here, we report on the synthesis of libraries of new 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones 3 (twenty-two compounds) and new 2-amino-5-arylidene-1,3-thiazol-4(5<i>H</i>)-ones 5 (twenty-four compounds) with stereo controlled <i>Z</i>-geometry under microwave irradiation....

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Bibliographic Details
Main Authors: Khadidja Bourahla, Solène Guihéneuf, Emmanuelle Limanton, Ludovic Paquin, Rémy Le Guével, Thierry Charlier, Mustapha Rahmouni, Emilie Durieu, Olivier Lozach, François Carreaux, Laurent Meijer, Jean-Pierre Bazureau
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pharmaceuticals
Subjects:
microwave
Knoevenagel condensation
sulphur/nitrogen displacement
1,3-thiazolidin-4-one
inhibition
protein kinase
Online Access:https://www.mdpi.com/1424-8247/14/11/1086

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https://www.mdpi.com/1424-8247/14/11/1086

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