Metabolically Abnormal Obesity Increases the Risk of Advanced Prostate Cancer in Chinese Patients Undergoing Radical Prostatectomy
Wen Liu,1 Wenxian Li,1 Zhankun Wang,2 Yao Zhu,3 Dingwei Ye,3 Guiming Zhang1 1Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Urology, Qingdao Eighth People’s Hospital, Qingdao, People’s Republic o...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2020-03-01
|
| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/metabolically-abnormal-obesity-increases-the-risk-of-advanced-prostate-peer-reviewed-article-CMAR |
| _version_ | 1818853373735075840 |
|---|---|
| author | Liu W Li W Wang Z Zhu Y Ye D Zhang G |
| author_facet | Liu W Li W Wang Z Zhu Y Ye D Zhang G |
| author_sort | Liu W |
| collection | DOAJ |
| description | Wen Liu,1 Wenxian Li,1 Zhankun Wang,2 Yao Zhu,3 Dingwei Ye,3 Guiming Zhang1 1Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Urology, Qingdao Eighth People’s Hospital, Qingdao, People’s Republic of China; 3Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of ChinaCorrespondence: Guiming ZhangDepartment of Urology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Road, Qingdao 266003, People’s Republic of ChinaTel +86-532 82913056Fax +86-532 82911999Email zhangguiming9@126.comBackground: To investigate the pathological risk of prostate cancer (PCa) according to the obesity and metabolic status of Chinese patients undergoing radical prostatectomy.Materials and Methods: We performed a retrospective cross-sectional study of 1016 patients with PCa who underwent radical prostatectomy and whose metabolic status and body mass index were examined. Multivariate logistic regression analysis was performed to examine the relationship between different metabolic obesity phenotypes and the pathological outcomes of PCa.Results: Among 1016 men, 551 (54.2%), 106 (10.4%), 238 (23.4%), and 121 (11.9%) were assigned to the metabolically healthy and normal weight (MHNW) group, metabolically abnormal but normal weight (MANW) group, metabolically healthy but overweight or obese (MHO) group, and metabolically abnormal and overweight or obese (MAO) group, respectively. Compared with the MHNW group, the MAO group had a significantly greater risk of a higher prostatectomy Gleason score [odds ratio (OR), 1.907; 95% confidence interval (95% CI), 1.144– 3.182], pathological stage (OR, 1.606; 95% CI, 1.035– 2.493), and seminal vesicle invasion (OR, 1.673; 95% CI, 1.041– 2.687). In contrast, the ORs were not increased in the MHO or MANW group. In the context of normal weight, metabolic disorders were associated with lymph node involvement. The metabolic status and body mass index were not associated with extracapsular extension or surgical margins in any of the four groups.Conclusion: The MAO phenotype is associated with aggressive PCa, including a higher prostatectomy Gleason score, pathological stage, and seminal vesicle invasion and might also be associated with disease progression. Obesity and metabolic disorders act synergistically to increase the pathological risk of PCa.Keywords: prostate cancer, obesity, metabolic syndrome, pathology, Gleason score |
| first_indexed | 2024-12-19T07:35:47Z |
| format | Article |
| id | doaj.art-f48652c0b12c4542905b029bd8aa0f00 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-19T07:35:47Z |
| publishDate | 2020-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-f48652c0b12c4542905b029bd8aa0f002022-12-21T20:30:36ZengDove Medical PressCancer Management and Research1179-13222020-03-01Volume 121779178752391Metabolically Abnormal Obesity Increases the Risk of Advanced Prostate Cancer in Chinese Patients Undergoing Radical ProstatectomyLiu WLi WWang ZZhu YYe DZhang GWen Liu,1 Wenxian Li,1 Zhankun Wang,2 Yao Zhu,3 Dingwei Ye,3 Guiming Zhang1 1Department of Urology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of China; 2Department of Urology, Qingdao Eighth People’s Hospital, Qingdao, People’s Republic of China; 3Department of Urology, Fudan University Shanghai Cancer Center, Shanghai, People’s Republic of ChinaCorrespondence: Guiming ZhangDepartment of Urology, The Affiliated Hospital of Qingdao University, No. 16, Jiangsu Road, Qingdao 266003, People’s Republic of ChinaTel +86-532 82913056Fax +86-532 82911999Email zhangguiming9@126.comBackground: To investigate the pathological risk of prostate cancer (PCa) according to the obesity and metabolic status of Chinese patients undergoing radical prostatectomy.Materials and Methods: We performed a retrospective cross-sectional study of 1016 patients with PCa who underwent radical prostatectomy and whose metabolic status and body mass index were examined. Multivariate logistic regression analysis was performed to examine the relationship between different metabolic obesity phenotypes and the pathological outcomes of PCa.Results: Among 1016 men, 551 (54.2%), 106 (10.4%), 238 (23.4%), and 121 (11.9%) were assigned to the metabolically healthy and normal weight (MHNW) group, metabolically abnormal but normal weight (MANW) group, metabolically healthy but overweight or obese (MHO) group, and metabolically abnormal and overweight or obese (MAO) group, respectively. Compared with the MHNW group, the MAO group had a significantly greater risk of a higher prostatectomy Gleason score [odds ratio (OR), 1.907; 95% confidence interval (95% CI), 1.144– 3.182], pathological stage (OR, 1.606; 95% CI, 1.035– 2.493), and seminal vesicle invasion (OR, 1.673; 95% CI, 1.041– 2.687). In contrast, the ORs were not increased in the MHO or MANW group. In the context of normal weight, metabolic disorders were associated with lymph node involvement. The metabolic status and body mass index were not associated with extracapsular extension or surgical margins in any of the four groups.Conclusion: The MAO phenotype is associated with aggressive PCa, including a higher prostatectomy Gleason score, pathological stage, and seminal vesicle invasion and might also be associated with disease progression. Obesity and metabolic disorders act synergistically to increase the pathological risk of PCa.Keywords: prostate cancer, obesity, metabolic syndrome, pathology, Gleason scorehttps://www.dovepress.com/metabolically-abnormal-obesity-increases-the-risk-of-advanced-prostate-peer-reviewed-article-CMARprostate cancerobesitymetabolic syndromepathologygleason score |
| spellingShingle | Liu W Li W Wang Z Zhu Y Ye D Zhang G Metabolically Abnormal Obesity Increases the Risk of Advanced Prostate Cancer in Chinese Patients Undergoing Radical Prostatectomy Cancer Management and Research prostate cancer obesity metabolic syndrome pathology gleason score |
| title | Metabolically Abnormal Obesity Increases the Risk of Advanced Prostate Cancer in Chinese Patients Undergoing Radical Prostatectomy |
| title_full | Metabolically Abnormal Obesity Increases the Risk of Advanced Prostate Cancer in Chinese Patients Undergoing Radical Prostatectomy |
| title_fullStr | Metabolically Abnormal Obesity Increases the Risk of Advanced Prostate Cancer in Chinese Patients Undergoing Radical Prostatectomy |
| title_full_unstemmed | Metabolically Abnormal Obesity Increases the Risk of Advanced Prostate Cancer in Chinese Patients Undergoing Radical Prostatectomy |
| title_short | Metabolically Abnormal Obesity Increases the Risk of Advanced Prostate Cancer in Chinese Patients Undergoing Radical Prostatectomy |
| title_sort | metabolically abnormal obesity increases the risk of advanced prostate cancer in chinese patients undergoing radical prostatectomy |
| topic | prostate cancer obesity metabolic syndrome pathology gleason score |
| url | https://www.dovepress.com/metabolically-abnormal-obesity-increases-the-risk-of-advanced-prostate-peer-reviewed-article-CMAR |
| work_keys_str_mv | AT liuw metabolicallyabnormalobesityincreasestheriskofadvancedprostatecancerinchinesepatientsundergoingradicalprostatectomy AT liw metabolicallyabnormalobesityincreasestheriskofadvancedprostatecancerinchinesepatientsundergoingradicalprostatectomy AT wangz metabolicallyabnormalobesityincreasestheriskofadvancedprostatecancerinchinesepatientsundergoingradicalprostatectomy AT zhuy metabolicallyabnormalobesityincreasestheriskofadvancedprostatecancerinchinesepatientsundergoingradicalprostatectomy AT yed metabolicallyabnormalobesityincreasestheriskofadvancedprostatecancerinchinesepatientsundergoingradicalprostatectomy AT zhangg metabolicallyabnormalobesityincreasestheriskofadvancedprostatecancerinchinesepatientsundergoingradicalprostatectomy |