DNA methylation in mice is influenced by genetics as well as sex and life experience
DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may ser...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-08067-z |
| _version_ | 1818753900722782208 |
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| author | Sara A. Grimm Takashi Shimbo Motoki Takaku James W. Thomas Scott Auerbach Brian D. Bennett John R. Bucher Adam B. Burkholder Frank Day Ying Du Christopher G. Duncan John E. French Julie F. Foley Jianying Li B. Alex Merrick Raymond R. Tice Tianyuan Wang Xiaojiang Xu NISC Comparative Sequencing Program Pierre R. Bushel David C. Fargo James C. Mullikin Paul A. Wade |
| author_facet | Sara A. Grimm Takashi Shimbo Motoki Takaku James W. Thomas Scott Auerbach Brian D. Bennett John R. Bucher Adam B. Burkholder Frank Day Ying Du Christopher G. Duncan John E. French Julie F. Foley Jianying Li B. Alex Merrick Raymond R. Tice Tianyuan Wang Xiaojiang Xu NISC Comparative Sequencing Program Pierre R. Bushel David C. Fargo James C. Mullikin Paul A. Wade |
| author_sort | Sara A. Grimm |
| collection | DOAJ |
| description | DNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology. |
| first_indexed | 2024-12-18T05:14:42Z |
| format | Article |
| id | doaj.art-f487b8a5e96d4b4596531537eeed2656 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T05:14:42Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f487b8a5e96d4b4596531537eeed26562022-12-21T21:19:48ZengNature PortfolioNature Communications2041-17232019-01-0110111310.1038/s41467-018-08067-zDNA methylation in mice is influenced by genetics as well as sex and life experienceSara A. Grimm0Takashi Shimbo1Motoki Takaku2James W. Thomas3Scott Auerbach4Brian D. Bennett5John R. Bucher6Adam B. Burkholder7Frank Day8Ying Du9Christopher G. Duncan10John E. French11Julie F. Foley12Jianying Li13B. Alex Merrick14Raymond R. Tice15Tianyuan Wang16Xiaojiang Xu17NISC Comparative Sequencing ProgramPierre R. Bushel18David C. Fargo19James C. Mullikin20Paul A. Wade21Division of Intramural Research, NIEHSDivision of Intramural Research, NIEHSDivision of Intramural Research, NIEHSNIH Intramural Sequencing Center, National Human Genome Research InstituteNational Toxicology Program, NIEHSDivision of Intramural Research, NIEHSNational Toxicology Program, NIEHSDivision of Intramural Research, NIEHSDivision of Intramural Research, NIEHSDivision of Intramural Research, NIEHSDivision of Intramural Research, NIEHSNational Toxicology Program, NIEHSNational Toxicology Program, NIEHSDivision of Intramural Research, NIEHSNational Toxicology Program, NIEHSNational Toxicology Program, NIEHSDivision of Intramural Research, NIEHSDivision of Intramural Research, NIEHSDivision of Intramural Research, NIEHSDivision of Intramural Research, NIEHSNIH Intramural Sequencing Center, National Human Genome Research InstituteDivision of Intramural Research, NIEHSDNA methylation is an epigenetic mark involved in gene regulation. Here the authors investigate the extent to which genetics, sex and pregnancy influence genomic DNA methylation in mice, providing evidence of the stability of CpG methylation across generation and suggest that CpG methylation may serve as an epigenetic record of life events in somatic tissues at loci whose expression is linked to the relevant biology.https://doi.org/10.1038/s41467-018-08067-z |
| spellingShingle | Sara A. Grimm Takashi Shimbo Motoki Takaku James W. Thomas Scott Auerbach Brian D. Bennett John R. Bucher Adam B. Burkholder Frank Day Ying Du Christopher G. Duncan John E. French Julie F. Foley Jianying Li B. Alex Merrick Raymond R. Tice Tianyuan Wang Xiaojiang Xu NISC Comparative Sequencing Program Pierre R. Bushel David C. Fargo James C. Mullikin Paul A. Wade DNA methylation in mice is influenced by genetics as well as sex and life experience Nature Communications |
| title | DNA methylation in mice is influenced by genetics as well as sex and life experience |
| title_full | DNA methylation in mice is influenced by genetics as well as sex and life experience |
| title_fullStr | DNA methylation in mice is influenced by genetics as well as sex and life experience |
| title_full_unstemmed | DNA methylation in mice is influenced by genetics as well as sex and life experience |
| title_short | DNA methylation in mice is influenced by genetics as well as sex and life experience |
| title_sort | dna methylation in mice is influenced by genetics as well as sex and life experience |
| url | https://doi.org/10.1038/s41467-018-08067-z |
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