<i>Smilax china</i> L. Polysaccharide Alleviates Dextran Sulphate Sodium-Induced Colitis and Modulates the Gut Microbiota in Mice
This work aimed to investigate the preventive effect of <i>Smilax china</i> L. polysaccharide (SCP) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. <i>Smilax china</i> L. polysaccharide was isolated by hot water extraction, ethanol precipitation, depr...
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MDPI AG
2023-04-01
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author | Xin Li Gaoxiang Qiao Lulu Chu Lezhen Lin Guodong Zheng |
author_facet | Xin Li Gaoxiang Qiao Lulu Chu Lezhen Lin Guodong Zheng |
author_sort | Xin Li |
collection | DOAJ |
description | This work aimed to investigate the preventive effect of <i>Smilax china</i> L. polysaccharide (SCP) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. <i>Smilax china</i> L. polysaccharide was isolated by hot water extraction, ethanol precipitation, deproteinization, and purification using DEAE-cellulose column chromatography to yield three polysaccharides: SCP_C, SCP_A, and SCP_N. Acute colitis was induced by administering 3% (<i>w</i>/<i>v</i>) DSS in drinking water for 7 days. Sulfasalazine, SCP_C, SCP_A, and SCP_N were administered by gavage for 9 days. SCP_C, SCP_A, and SCP_N could significantly improve symptoms, as evidenced by the declining disease activity index (DAI), decreased spleen weight, increased length of the colon, and improved colonic histology. Moreover, SCP_C, SCP_A, and SCP_N increased serum glutathione and decreased the levels of pro-inflammatory cytokines, malondialdehyde, nitric oxide, and myeloperoxidase in colon tissues. Additionally, SCP_C, SCP_A, and SCP_N modulated gut microbiota via ascending the growth of <i>Lachnospiraceae</i>, <i>Muribaculaceae</i>, <i>Blautia</i>, and <i>Mucispirillum</i> and descending the abundance of <i>Akkermansiaceae</i>, <i>Deferribacteraceae</i>, and <i>Oscillibacter</i> in mice with UC. The results suggested that <i>Smilax china</i> L. polysaccharide ameliorates oxidative stress, balances inflammatory cytokines, and modulates gut microbiota, providing an effective therapeutic strategy for UC in mice. |
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last_indexed | 2024-03-11T05:01:39Z |
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spelling | doaj.art-f489ff159c7943a4bf2c0383d1ed887c2023-11-17T19:14:27ZengMDPI AGFoods2304-81582023-04-01128163210.3390/foods12081632<i>Smilax china</i> L. Polysaccharide Alleviates Dextran Sulphate Sodium-Induced Colitis and Modulates the Gut Microbiota in MiceXin Li0Gaoxiang Qiao1Lulu Chu2Lezhen Lin3Guodong Zheng4Jiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Key Laboratory of Natural Product and Functional Food, College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang 330045, ChinaThis work aimed to investigate the preventive effect of <i>Smilax china</i> L. polysaccharide (SCP) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice. <i>Smilax china</i> L. polysaccharide was isolated by hot water extraction, ethanol precipitation, deproteinization, and purification using DEAE-cellulose column chromatography to yield three polysaccharides: SCP_C, SCP_A, and SCP_N. Acute colitis was induced by administering 3% (<i>w</i>/<i>v</i>) DSS in drinking water for 7 days. Sulfasalazine, SCP_C, SCP_A, and SCP_N were administered by gavage for 9 days. SCP_C, SCP_A, and SCP_N could significantly improve symptoms, as evidenced by the declining disease activity index (DAI), decreased spleen weight, increased length of the colon, and improved colonic histology. Moreover, SCP_C, SCP_A, and SCP_N increased serum glutathione and decreased the levels of pro-inflammatory cytokines, malondialdehyde, nitric oxide, and myeloperoxidase in colon tissues. Additionally, SCP_C, SCP_A, and SCP_N modulated gut microbiota via ascending the growth of <i>Lachnospiraceae</i>, <i>Muribaculaceae</i>, <i>Blautia</i>, and <i>Mucispirillum</i> and descending the abundance of <i>Akkermansiaceae</i>, <i>Deferribacteraceae</i>, and <i>Oscillibacter</i> in mice with UC. The results suggested that <i>Smilax china</i> L. polysaccharide ameliorates oxidative stress, balances inflammatory cytokines, and modulates gut microbiota, providing an effective therapeutic strategy for UC in mice.https://www.mdpi.com/2304-8158/12/8/1632<i>Smilax china</i> L. polysaccharidesoxidative stressintestinal inflammationulcerative colitisgut microbiota |
spellingShingle | Xin Li Gaoxiang Qiao Lulu Chu Lezhen Lin Guodong Zheng <i>Smilax china</i> L. Polysaccharide Alleviates Dextran Sulphate Sodium-Induced Colitis and Modulates the Gut Microbiota in Mice Foods <i>Smilax china</i> L. polysaccharides oxidative stress intestinal inflammation ulcerative colitis gut microbiota |
title | <i>Smilax china</i> L. Polysaccharide Alleviates Dextran Sulphate Sodium-Induced Colitis and Modulates the Gut Microbiota in Mice |
title_full | <i>Smilax china</i> L. Polysaccharide Alleviates Dextran Sulphate Sodium-Induced Colitis and Modulates the Gut Microbiota in Mice |
title_fullStr | <i>Smilax china</i> L. Polysaccharide Alleviates Dextran Sulphate Sodium-Induced Colitis and Modulates the Gut Microbiota in Mice |
title_full_unstemmed | <i>Smilax china</i> L. Polysaccharide Alleviates Dextran Sulphate Sodium-Induced Colitis and Modulates the Gut Microbiota in Mice |
title_short | <i>Smilax china</i> L. Polysaccharide Alleviates Dextran Sulphate Sodium-Induced Colitis and Modulates the Gut Microbiota in Mice |
title_sort | i smilax china i l polysaccharide alleviates dextran sulphate sodium induced colitis and modulates the gut microbiota in mice |
topic | <i>Smilax china</i> L. polysaccharides oxidative stress intestinal inflammation ulcerative colitis gut microbiota |
url | https://www.mdpi.com/2304-8158/12/8/1632 |
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