Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data.
Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many tumors harbor a variety of subpopulations with distinct therapeutic response characteristics. Characterizing this heterogeneity by determining...
Main Authors: | Chenyu Wu, Einar Bjarki Gunnarsson, Even Moa Myklebust, Alvaro Köhn-Luque, Dagim Shiferaw Tadele, Jorrit Martijn Enserink, Arnoldo Frigessi, Jasmine Foo, Kevin Leder |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2024-03-01
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Series: | PLoS Computational Biology |
Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011888&type=printable |
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